FOXA1/CK7-positive Esophageal Squamous Cell Carcinoma with Aggressive Liver Metastasis: A Case Report

Cytokeratin (CK) is a specific marker of adenocarcinoma. However, cases of CK7-positive esophageal squamous cell carcinoma (ESCC) have only rarely been reported. We herein report a case of unresectable CK7-positive ESCC with aggressive liver metastasis following nivolumab treatment initiation. Nivol...

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Published inInternal Medicine p. 3300-23
Main Authors Inoue, Hiroto, Inatomi, Osamu, Matsumoto, Hiroshi, Kimura, Hidenori, Nakayama, Takahisa, Nishida, Atsushi, Andoh, Akira
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 2024
Subjects
CK7
esophageal squamous cell carcinoma
FOXA1
immune checkpoint inhibitor
FOXA1
esophageal squamous cell carcinoma
immune checkpoint inhibitor
CK7
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Summary:Cytokeratin (CK) is a specific marker of adenocarcinoma. However, cases of CK7-positive esophageal squamous cell carcinoma (ESCC) have only rarely been reported. We herein report a case of unresectable CK7-positive ESCC with aggressive liver metastasis following nivolumab treatment initiation. Nivolumab treatment was discontinued after one course because of complications. Notably, the liver metastases exhibited accelerated growth. Immunostaining of the necropsy specimens revealed diffuse positivity for forkhead box protein A1 (FOXA1)/CK7, thus indicating a potent poor immune response. The potential correlation between CK7 expression and the immune checkpoint inhibitor response may offer valuable insights into the development of effective therapeutic strategies.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.3300-23