Preparation and in vitro evaluation of a novel amphiphilic GdPCTA-[12] derivative; a micellar MRI contrast agent

A novel amphiphilic GdPCTA-[12] derivative has been prepared. The complex formed micelles in aqueous solution with a relatively low CMC, 0.15 mM (25 degreesC). The concentration dependent T-1-relaxivity (r(1)) of the system has been described. The maximum T-1-relaxivity, 29.2 s(-1) mM(-1) (20 MHz, 2...

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Published inOrganic & biomolecular chemistry Vol. 1; no. 4; pp. 644 - 647
Main Authors Hovland, R, Glogard, C, Aasen, AJ, Klaveness, J
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.02.2003
Subjects
Chemistry
Chemistry, Organic
Contrast Media - chemical synthesis
Gadolinium DTPA - chemical synthesis
Magnetic Resonance Imaging
Micelles
Physical Sciences
Science & Technology
Solutions
Surface-Active Agents - chemical synthesis
Water
LIGANDS
COMPLEXES
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Summary:A novel amphiphilic GdPCTA-[12] derivative has been prepared. The complex formed micelles in aqueous solution with a relatively low CMC, 0.15 mM (25 degreesC). The concentration dependent T-1-relaxivity (r(1)) of the system has been described. The maximum T-1-relaxivity, 29.2 s(-1) mM(-1) (20 MHz, 25 degreesC), was higher than for previously described micellar MRI contrast agents. This high T-1-relaxivity is a consequence of the favourable water residence time (tau(m)) and the fact that the complex is heptadentate allowing two water molecules to coordinate to the gadolinium ion (q = 2).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1477-0520
1477-0539
DOI:10.1039/b211039c