Does off-hours endoscopic hemostasis affect outcomes of nonvariceal upper gastrointestinal bleeding?

• Published in: Journal of comparative effectiveness research Vol. 11; no. 3; pp. 275 - 283
• Main Authors: Guan, Jia-Lun, Wang, Ge, Fang, Dan, Han, Ying-Ying, Wang, Mu-Ru, Tian, De-An, Li, Pei-Yuan
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.03.2022
• Subjects: clinical outcomes; endoscopic hemostasis; Glasgow–Blatchford score; nonvariceal upper gastrointestinal bleeding; off-hours effect; clinical outcomes; Glasgow–Blatchford score; nonvariceal upper gastrointestinal bleeding; off-hours effect; endoscopic hemostasis
• ISSN: 2042-6305; 2042-6313
• DOI: 10.2217/cer-2021-0155

Different researches showed controversial results about the ‘off-hours effect’ in nonvariceal upper gastrointestinal bleeding (NVUGIB). A total of 301 patients with NVUGIB were divided into regular-hours group and off-hours group based on when they received endoscopic hemostasis, and the relationship of the clinical outcomes with off-hours endoscopic hemostasis was evaluated. Patients who received off-hours endoscopy were sicker and more likely to experience worse clinical outcomes. Off-hours endoscopic hemostasis was a significant predictor of the composite outcome in higher-risk patients (adjusted OR: 4.63; 95% CI: 1.35–15.90). However, it did not associate with the outcomes in lower-risk patients. Off-hours effect may affect outcomes of higher-risk NVUGIB patients receiving endoscopic hemostasis (GBS ≥12).