Antimicrobial Resistance Patterns of Pathogens Isolated from Patients with Wound Infection at a Teaching Hospital in Vietnam

• Published in: Infection and drug resistance Vol. 17; pp. 3463 - 3473
• Main Authors: An, Nguyen Van, Kien, Hoang Trung, Hoang, Le Huy, Cuong, Nguyen Hung, Quang, Hoang Xuan, Le, Tuan Dinh, Thang, Ta Ba, Viet, Tien Tran, Thuc, Luong Cong, Hung, Dinh Viet, Viet, Nguyen Hoang, Minh, Le Nhat, Luong, Vu Huy, Nguyen, Vinh Thi Ha, Hoa, Pham Quynh, Le, Hai Ha Long
• Format: Journal Article
• Language: English
• Published: New Zealand Dove 01.01.2024; Dove Medical Press
• Subjects: amr in vietnam; antimicrobial resistance; multidrug resistance; Original Research; wound infection; multidrug resistance; AMR in Vietnam; wound infection; antimicrobial resistance
• ISSN: 1178-6973; 1178-6973
• DOI: 10.2147/IDR.S472025

At a teaching Hospital in Vietnam, the persistently high incidence of diagnosed wound infection poses ongoing challenges to treatment. This study seeks to explore the causative agents of wound infection and their antimicrobial and multidrug resistance patterns. A cross-sectional study was conducted at the Department of Microbiology, Military Hospital 103, Vietnam. Data on microorganisms that caused wound infection and their antimicrobial resistance patterns was recorded from hospitalized patients from 2014 to 2021. Using the chi-square test, we analyzed the initial isolation from wound infection specimens collected from individual patients. Over a third (34.9%) of wound infection samples yielded bacterial cultures. was the most prevalent bacteria, followed by . Worryingly high resistance rates were observed for several antibiotics, particularly among Gram-negative bacteria. Ampicillin displayed the highest resistance (91.9%), while colistin and ertapenem remained the most effective. In Gram-positive bacteria, glycopeptides like teicoplanin and vancomycin (0% and 3.3% resistance, respectively) were most effective, but their use was limited. Clindamycin and tetracycline showed decreasing effectiveness. Resistance rates differed between surgical and non-surgical wards, highlighting the complex dynamics of antimicrobial resistance within hospitals. Multidrug resistance (MDR) was substantial, with Gram-negative bacteria exhibiting a 63.6% MDR rate. showed the highest MDR rate (88.0%). This study investigated wound infection characteristics, antibiotic resistance patterns of common bacteria, and variations by hospital ward. was the most prevalent bacteria, and concerning resistance rates were observed, particularly among Gram-negative bacteria. These findings highlight the prevalence of multidrug resistance in wound infections, emphasizing the importance of infection control measures and judicious antibiotic use.