The Key Role of Glutathione Compared to Curcumin in the Management of Systemic Lupus Erythematosus: A Systematic Review

• Published in: Curēus (Palo Alto, CA) Vol. 14; no. 11; p. e31324
• Main Authors: Ravi, Niriksha, Choday, Silpa, Shantha Kumar, Vivig, Kc, Anil, Parisapogu, Anusha, Ojinna, Blessing T, Tran, Hadrian Hoang-Vu, Sherpa, Mingma L, Shrestha, Nilasma, Mohammed, Lubna
• Format: Journal Article
• Language: English
• Published: United States Cureus Inc 10.11.2022; Cureus
• Subjects: Adaptive immunity; Bias; Bone marrow; Drug dosages; Drug therapy; Epidemiology; Immunology; Internal Medicine; Lupus; Pathophysiology; Pharmacokinetics; Physiology; Quality Improvement; Remission (Medicine); Rheumatology; Systematic review; Tumor necrosis factor-TNF; glutathione and lupus; autoimmune disorders; systemic lupus erythematosus; lupus treatment alternatives; new advances in sle; glutathione; curcumin and lupus; sle oxidative pathways; sle pathogenesis; curcumin
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.31324

In recent years, many documented cases of systemic lupus erythematosus (SLE) have been on the rise. The complicated pathophysiology of the disease makes it challenging to manage. Two databases, PubMed and Google Scholar, have a detailed screening using keywords and Medical Subject Heading (MeSH) combinations. The words are "Systemic Lupus Erythematosus OR SLE OR Lupus," "Glutathione," and "Curcumin." Articles had a detailed process of screening and quality appraisal. Using the English language as a primary filtering parameter, papers over the last 20 years, dating from 2002 to 2022, are the basis of this review. We reviewed all possible human studies documenting the use of curcumin and glutathione for treating SLE. A total of 15 articles are part of this systematic review. Curcumin and glutathione can act as potent drugs for treating lupus. Curcumin can be a more promising alternative since it operates on various pathways and is a more easily accessible source.