An efficient preparative route to 7-ethyl-1H-furo[2,3-g]indazole

A new and efficient route to 7-ethyl-1H-furo[2,3-g]indazole (2) has been developed. Treatment of 4,5-dihydro-7-(1-hydroxyethyl)indazole (12) with hydrochloric acid in ethanol resulted in a concomitant dehydration and aromatization to afford the title compound in good yield.

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Bibliographic Details
Published inHeterocycles Vol. 62; pp. 807 - 813
Main Authors Shimada, Maeno, K, Kimizuka, T, Goto, S, Takahashi, T, Nakamura, A, Miyafuji, A, Tsukamoto, S, Sakamoto, S
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.01.2004
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
synthesis
aromatization
multi-kilogram
YM348
dehydration
RECEPTORS
5-HT2C receptor agonist
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Summary:A new and efficient route to 7-ethyl-1H-furo[2,3-g]indazole (2) has been developed. Treatment of 4,5-dihydro-7-(1-hydroxyethyl)indazole (12) with hydrochloric acid in ethanol resulted in a concomitant dehydration and aromatization to afford the title compound in good yield.
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-03-S(P)26