An integrative model of cancer cell differentiation with immunotherapy
In order to improve cancer treatments, cancer cell differentiation and immunotherapy are the subjects of several studies in different branches of interdisciplinary sciences. In this work, we develop a new population model that integrates other complementary ones, thus emphasizing the relationship be...
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| Published in | Physical biology Vol. 18; no. 6; p. 66007 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.11.2021
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| Subjects | |
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| Abstract | In order to improve cancer treatments, cancer cell differentiation and immunotherapy are the subjects of several studies in different branches of interdisciplinary sciences. In this work, we develop a new population model that integrates other complementary ones, thus emphasizing the relationship between cancer cells at different differentiation stages and the main immune system cells. For this new system, specific ranges were found where transdifferentiation of differentiated cancer cells can occur. In addition, a specific therapy against cancer stem cells was analysed by simulating cytotoxic cell vaccines. In reference to the latter, the different combinations of parameters that optimize it were studied. |
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| AbstractList | In order to improve cancer treatments, cancer cell differentiation and immunotherapy are the subjects of several studies in different branches of interdisciplinary sciences. In this work, we develop a new population model that integrates other complementary ones, thus emphasizing the relationship between cancer cells at different differentiation stages and the main immune system cells. For this new system, specific ranges were found where transdifferentiation of differentiated cancer cells can occur. In addition, a specific therapy against cancer stem cells was analysed by simulating cytotoxic cell vaccines. In reference to the latter, the different combinations of parameters that optimize it were studied.In order to improve cancer treatments, cancer cell differentiation and immunotherapy are the subjects of several studies in different branches of interdisciplinary sciences. In this work, we develop a new population model that integrates other complementary ones, thus emphasizing the relationship between cancer cells at different differentiation stages and the main immune system cells. For this new system, specific ranges were found where transdifferentiation of differentiated cancer cells can occur. In addition, a specific therapy against cancer stem cells was analysed by simulating cytotoxic cell vaccines. In reference to the latter, the different combinations of parameters that optimize it were studied. In order to improve cancer treatments, cancer cell differentiation and immunotherapy are the subjects of several studies in different branches of interdisciplinary sciences. In this work, we develop a new population model that integrates other complementary ones, thus emphasizing the relationship between cancer cells at different differentiation stages and the main immune system cells. For this new system, specific ranges were found where transdifferentiation of differentiated cancer cells can occur. In addition, a specific therapy against cancer stem cells was analysed by simulating cytotoxic cell vaccines. In reference to the latter, the different combinations of parameters that optimize it were studied. |
| Author | Margarit, David H Romanelli, Lilia M Reale, Marcela V González, Nadia S Fendrik, Alejandro J Scagliotti, Ariel F |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34633296$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1007/978-3-319-64096-9_7 10.1016/j.envint.2021.106624 10.1103/physreva.26.1676 10.1093/jnci/djab139 10.3390/cancers13030433 10.3390/cancers13081872 10.1007/978-981-15-9038-2_3 10.1126/scitranslmed.aav7431 10.1002/jlb.4ru0819-150rr 10.3389/fphy.2019.00083 10.3390/axioms7040091 10.1038/s41590-020-0728-z 10.1371/journal.pone.0254991 10.1088/1742-5468/2016/05/054032 10.1016/j.tranon.2020.100889 10.1088/1478-3975/7/3/034001 10.1158/1078-0432.ccr-20-0473 10.1038/s41416-020-01048-4 10.1140/epjb/e2008-00246-2 10.1126/scitranslmed.aan2415 10.1111/joim.12963 10.2174/1574888x15999200831160710 10.1016/bs.acr.2020.05.001 10.1007/s00217-008-0988-6 10.1038/s41571-020-0426-7 10.1016/j.rmed.2019.105843 10.1007/s12064-011-0127-y 10.1016/j.lfs.2020.118005 10.1158/2159-8290.cd-20-0756 10.1188/14.onf.286-295 10.1186/s12913-016-1944-y 10.1007/s40272-018-0297-x 10.1016/j.biocel.2020.105861 10.1016/j.gene.2018.09.052 10.1142/s0218339015400033 10.1016/j.stem.2021.02.001 10.1016/j.actbio.2020.07.063 10.7150/thno.41647 10.1038/s41571-020-00460-2 10.1038/srep24169 10.31557/apjcp.2020.21.11.3301 10.1371/journal.pone.0224787 10.1155/2019/4107917 10.1016/j.jtbi.2018.01.006 10.1371/journal.pcbi.1005920 10.3390/cells10061528 10.1088/1478-3975/ac0b7e 10.1245/s10434-019-07963-y 10.1186/s12916-020-01899-x 10.1016/j.tcb.2020.07.003 10.1038/s41598-020-65590-0 10.1101/cshperspect.a026781 10.1016/j.smim.2021.101481 10.3747/co.27.5223 10.1038/s41568-019-0124-x 10.3389/fonc.2021.609054 10.1063/1.3140529 10.1039/d0sc06557a 10.1002/0471141755.ph1425s61 10.1002/psp4.12450 10.1007/s12015-020-10114-6 10.1093/carcin/bgaa114 10.1172/jci145971 10.1016/j.mbs.2019.108269 10.1038/s41598-018-19552-2 10.1002/1878-0261.12772 10.1088/1361-6560/abc3fc 10.1007/s12272-015-0558-y 10.1097/md.0000000000004764 10.1016/j.canlet.2018.09.019 10.1016/j.ecocom.2012.10.002 10.1103/revmodphys.70.223 10.1111/eva.12994 10.1142/s0218127421500887 10.1080/21645515.2021.1903827 10.1038/s41598-018-27362-9 10.3390/jcm9010084 10.1088/0953-8984/14/9/313 10.1016/j.lfs.2019.116781 10.3389/fmolb.2020.00079 10.3390/cancers13030376 10.1038/s41588-020-00752-4 10.1016/j.matpur.2021.01.007 10.1038/s41698-017-0039-5 10.1140/epjb/e2004-00268-8 10.1084/jem.20061890 10.1007/s12032-020-01447-w 10.1016/j.cels.2020.11.013 10.3389/fimmu.2020.01280 10.1016/j.trecan.2020.03.011 10.1007/s00018-019-03351-7 |
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| References | Van Egeren (pbac2e72bib21) 2021; 28 Lugano (pbac2e72bib94) 2020; 77 Sardanyés (pbac2e72bib28) 2018; 8 Denaro (pbac2e72bib55) 2013; 13 Cole (pbac2e72bib23) 2020; 10 Yuan (pbac2e72bib88) 2021; 12 Pizzolato (pbac2e72bib27) 2011; 130 Livingstone (pbac2e72bib16) 2020; 27 Friedenreich (pbac2e72bib3) 2021; 15 Thankamony (pbac2e72bib24) 2020; 7 Carollo (pbac2e72bib99) 2018; 8 Ogale (pbac2e72bib80) 2021 Di Bona (pbac2e72bib78) 2020; 161 Zhang (pbac2e72bib60) 2017 Albrecht (pbac2e72bib11) 2014; 41 Marciscano (pbac2e72bib33) 2021 Teimouri (pbac2e72bib4) 2021; 18 Huang (pbac2e72bib89) 2021; 14 Raskov (pbac2e72bib34) 2021; 124 Quaglino (pbac2e72bib92) 2020; 129 Najafi (pbac2e72bib51) 2019; 234 Sigal (pbac2e72bib42) 2019; 318 Cardone (pbac2e72bib59) 2018; 7 Upadhyay (pbac2e72bib70) 2021; 11 Marzagalli (pbac2e72bib49) 2021; 13 Jain (pbac2e72bib37) 2021; 13 Teleanu (pbac2e72bib62) 2020; 9 Hirata (pbac2e72bib63) 2017; 7 Murphy (pbac2e72bib10) 2016 Tagliaferri (pbac2e72bib14) 2021; 17 David (pbac2e72bib61) 2021; 155 Bald (pbac2e72bib46) 2020; 21 Jang (pbac2e72bib75) 2015; 38 Khosravi (pbac2e72bib90) 2020; 256 Valero (pbac2e72bib86) 2021; 53 Bakir (pbac2e72bib64) 2020; 10 Sikdar (pbac2e72bib66) 2017; 17 Hansen (pbac2e72bib9) 2020; 13 Mayoux (pbac2e72bib45) 2020; 12 Rich (pbac2e72bib76) 2016; 95 Graham (pbac2e72bib96) 1982; 26 Shariatpanahi (pbac2e72bib41) 2018; 442 Majidpoor (pbac2e72bib8) 2021; 38 Tcyganov (pbac2e72bib32) 2021; 131 Bose (pbac2e72bib82) 2019; 2109 Lucarini (pbac2e72bib73) 2021; 13 Zarnani (pbac2e72bib71) 2021 Boissonnas (pbac2e72bib44) 2007; 204 Esfahani (pbac2e72bib12) 2020; 27 Nazari (pbac2e72bib48) 2018; 14 Trebeschi (pbac2e72bib85) 2021; 11 Samuel (pbac2e72bib74) 2021; 289 Bao (pbac2e72bib50) 2013; 61 Champiat (pbac2e72bib84) 2021; 27 Banstola (pbac2e72bib17) 2020; 114 Myers (pbac2e72bib31) 2021; 18 Kuoğşlu (pbac2e72bib25) 2019; 681 Núñez-López (pbac2e72bib38) 2021; 31 Walcher (pbac2e72bib93) 2020; 11 Gammaitoni (pbac2e72bib95) 1998; 70 Li (pbac2e72bib72) 2021; 12 Liu (pbac2e72bib22) 2021; 17 Baar (pbac2e72bib54) 2016; 6 Yin (pbac2e72bib26) 2019; 8 Somanna (pbac2e72bib65) 2020; 21 Heitzer (pbac2e72bib67) 2017; 1 Wadkin (pbac2e72bib87) 2021 Diambra (pbac2e72bib58) 2019; 7 Li (pbac2e72bib77) 2017 Tsygvintsev (pbac2e72bib39) 2013 Mikhailov (pbac2e72bib30) 2013; vol 52 Seton-Rogers (pbac2e72bib7) 2019; 19 (pbac2e72bib1) 2021 Phallen (pbac2e72bib68) 2017; 9 Zhang (pbac2e72bib69) 2021; 19 Spagnolo (pbac2e72bib97) 2004; 40 Zhu (pbac2e72bib18) 2020; 148 Wilson (pbac2e72bib19) 2020; 6 Bessonov (pbac2e72bib52) 2019; 14 Valentinuzzi (pbac2e72bib13) 2020; 65 Patel (pbac2e72bib6) 2020; 41 Barupal (pbac2e72bib5) 2021; 156 Kuzina (pbac2e72bib43) 2019 Fiasconaro (pbac2e72bib35) 2008; 65 Pizzolato (pbac2e72bib57) 2010; 7 Harrandah (pbac2e72bib15) 2018; 438 Giuffrida (pbac2e72bib56) 2009; 228 Blass (pbac2e72bib79) 2021; 18 Coletti (pbac2e72bib36) 2020; 10 Wedekind (pbac2e72bib83) 2018; 20 Eaton (pbac2e72bib81) 2021 Bahmad (pbac2e72bib20) 2021; 16 Klein (pbac2e72bib2) 2021 Pizzolato (pbac2e72bib29) 2016 Skvortsova (pbac2e72bib91) 2021; 10 Margarit (pbac2e72bib40) 2015; 23 Sanaei (pbac2e72bib47) 2020; 107 Spagnolo (pbac2e72bib53) 2009; 1129 Spagnolo (pbac2e72bib98) 2002; 14 |
| References_xml | – start-page: 99 year: 2017 ident: pbac2e72bib77 doi: 10.1007/978-3-319-64096-9_7 – volume: 156 year: 2021 ident: pbac2e72bib5 article-title: Prioritizing cancer hazard assessments for IARC monographs using an integrated approach of database fusion and text mining publication-title: Environ. Int. doi: 10.1016/j.envint.2021.106624 – volume: 26 start-page: 1676 year: 1982 ident: pbac2e72bib96 article-title: Stabilization by multiplicative noise publication-title: Phys. Rev. A doi: 10.1103/physreva.26.1676 – start-page: djab139 year: 2021 ident: pbac2e72bib2 article-title: Behavioral research in cancer prevention and control: emerging challenges and opportunities publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/djab139 – volume: 13 start-page: 433 year: 2021 ident: pbac2e72bib73 article-title: Dendritic cells: behind the scenes of T-cell infiltration into the tumour microenvironment publication-title: Cancers doi: 10.3390/cancers13030433 – volume: 13 start-page: 1872 year: 2021 ident: pbac2e72bib37 article-title: Standing variations modeling captures inter-individual heterogeneity in a deterministic model of prostate cancer response to combination therapy publication-title: Cancers doi: 10.3390/cancers13081872 – start-page: 31 year: 2021 ident: pbac2e72bib80 article-title: Vaccines as immunotherapy doi: 10.1007/978-981-15-9038-2_3 – volume: 12 year: 2020 ident: pbac2e72bib45 article-title: Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy publication-title: Sci. Trans. Med. doi: 10.1126/scitranslmed.aav7431 – volume: 107 start-page: 43 year: 2020 ident: pbac2e72bib47 article-title: Crosstalk between myeloid-derived suppressor cells and the immune system in prostate cancer: MDSCs and immune system in Prostate cancer publication-title: J. Leukocyte Biol. doi: 10.1002/jlb.4ru0819-150rr – year: 2021 ident: pbac2e72bib81 – volume: 7 start-page: 83 year: 2019 ident: pbac2e72bib58 article-title: Emergent effects of noise in biology: from gene expression to cell motility publication-title: Front. Phys. doi: 10.3389/fphy.2019.00083 – volume: 7 start-page: 91 year: 2018 ident: pbac2e72bib59 article-title: Stability issues for selected stochastic evolutionary problems: a review publication-title: Axioms doi: 10.3390/axioms7040091 – start-page: 1 year: 2019 ident: pbac2e72bib43 article-title: Mathematical modeling of anti-tumour vaccinotherapy: the interaction of immune system with tumour cells – volume: 21 start-page: 835 year: 2020 ident: pbac2e72bib46 article-title: The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies publication-title: Nat. Immunol. doi: 10.1038/s41590-020-0728-z – year: 2021 ident: pbac2e72bib87 article-title: A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells doi: 10.1371/journal.pone.0254991 – year: 2016 ident: pbac2e72bib29 article-title: Intermittent targeted therapies and stochastic evolution in patients affected by chronic myeloid leukemia publication-title: J. Stat. Mech. doi: 10.1088/1742-5468/2016/05/054032 – volume: 14 year: 2021 ident: pbac2e72bib89 article-title: Combination therapy: future directions of immunotherapy in small cell lung cancer publication-title: Transl. Oncol. doi: 10.1016/j.tranon.2020.100889 – volume: 7 year: 2010 ident: pbac2e72bib57 article-title: Resonant activation in polymer translocation: new insights into the escape dynamics of molecules driven by an oscillating field publication-title: Phys. Biol. doi: 10.1088/1478-3975/7/3/034001 – volume: 27 start-page: 665 year: 2021 ident: pbac2e72bib84 article-title: Intratumoural immunotherapy: from trial design to clinical practice publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.ccr-20-0473 – volume: 124 start-page: 359 year: 2021 ident: pbac2e72bib34 article-title: Cytotoxic CD8+ T cells in cancer and cancer immunotherapy publication-title: Br. J. Cancer doi: 10.1038/s41416-020-01048-4 – volume: 65 start-page: 435 year: 2008 ident: pbac2e72bib35 article-title: Monitoring noise-resonant effects in cancer growth influenced by external fluctuations and periodic treatment publication-title: Eur. Phys. J. B doi: 10.1140/epjb/e2008-00246-2 – volume: 9 year: 2017 ident: pbac2e72bib68 article-title: Direct detection of early-stage cancers using circulating tumour DNA publication-title: Sci. Trans. Med. doi: 10.1126/scitranslmed.aan2415 – volume: 289 start-page: 138 year: 2021 ident: pbac2e72bib74 article-title: Personalized medicine and back-allogeneic exosomes for cancer immunotherapy publication-title: J. Intern. Med. doi: 10.1111/joim.12963 – volume: 16 start-page: 262 year: 2021 ident: pbac2e72bib20 article-title: Stem cells: in sickness and in health publication-title: Curr. Stem Cell Res. Ther. doi: 10.2174/1574888x15999200831160710 – volume: 148 start-page: 1 year: 2020 ident: pbac2e72bib18 article-title: Epigenetic regulation of cancer stem cell and tumorigenesis publication-title: Adv. Cancer Res. doi: 10.1016/bs.acr.2020.05.001 – volume: 228 start-page: 767 year: 2009 ident: pbac2e72bib56 article-title: A stochastic interspecific competition model to predict the behaviour of Listeria monocytogenes in the fermentation process of a traditional Sicilian salami publication-title: Eur. Food Res. Technol. doi: 10.1007/s00217-008-0988-6 – volume: 18 start-page: 85 year: 2021 ident: pbac2e72bib31 article-title: Exploring the NK cell platform for cancer immunotherapy publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/s41571-020-0426-7 – volume: 161 year: 2020 ident: pbac2e72bib78 article-title: Safety and treatment compliance of subcutaneous immunotherapy: a 30 year retrospective study publication-title: Respir. Med. doi: 10.1016/j.rmed.2019.105843 – volume: 130 start-page: 203 year: 2011 ident: pbac2e72bib27 article-title: Stochastic dynamics of leukemic cells under an intermittent targeted therapy publication-title: Theory Biosci. doi: 10.1007/s12064-011-0127-y – volume: 256 year: 2020 ident: pbac2e72bib90 article-title: Immune checkpoints in tumour microenvironment and their relevance to the development of cancer stem cells publication-title: Life Sci. doi: 10.1016/j.lfs.2020.118005 – volume: 11 start-page: 599 year: 2021 ident: pbac2e72bib70 article-title: A critical role for Fas-mediated off-target tumour killing in T-cell immunotherapy publication-title: Cancer Discovery doi: 10.1158/2159-8290.cd-20-0756 – volume: 41 start-page: 286 year: 2014 ident: pbac2e72bib11 article-title: Physiologic and psychological symptoms experienced by adults with acute leukemia: an integrative literature review publication-title: Oncol. Nurs. Forum doi: 10.1188/14.onf.286-295 – volume: 17 start-page: 7 year: 2017 ident: pbac2e72bib66 article-title: Factors associated with mode of colorectal cancer detection and time to diagnosis: a population level study publication-title: BMC Health Serv. Res. doi: 10.1186/s12913-016-1944-y – volume: 20 start-page: 395 year: 2018 ident: pbac2e72bib83 article-title: Pediatric cancer immunotherapy: opportunities and challenges publication-title: Pediatr. Drugs doi: 10.1007/s40272-018-0297-x – volume: 129 year: 2020 ident: pbac2e72bib92 article-title: Cancer stem cell antigens as targets for new combined anti-cancer therapies publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2020.105861 – volume: 681 start-page: 80 year: 2019 ident: pbac2e72bib25 article-title: Cancer stem cells: a brief review of the current status publication-title: Gene doi: 10.1016/j.gene.2018.09.052 – volume: 23 start-page: S33 year: 2015 ident: pbac2e72bib40 article-title: A simple model for control of tumour cells publication-title: J. Biol. Syst. doi: 10.1142/s0218339015400033 – volume: 28 start-page: 514 year: 2021 ident: pbac2e72bib21 article-title: Reconstructing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms publication-title: Cell Stem Cell doi: 10.1016/j.stem.2021.02.001 – volume: 114 start-page: 16 year: 2020 ident: pbac2e72bib17 article-title: Immunoadjuvants for cancer immunotherapy: a review of recent developments publication-title: Acta Biomater. doi: 10.1016/j.actbio.2020.07.063 – volume: 10 start-page: 3083 year: 2020 ident: pbac2e72bib23 article-title: An evolving paradigm of cancer stem cell hierarchies: therapeutic implications publication-title: Theranostics doi: 10.7150/thno.41647 – volume: 18 start-page: 21 year: 2021 ident: pbac2e72bib79 article-title: Advances in the development of personalized neoantigen-based therapeutic cancer vaccines publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/s41571-020-00460-2 – year: 2021 ident: pbac2e72bib1 – volume: vol 52 year: 2013 ident: pbac2e72bib30 – volume: 6 start-page: 24169 year: 2016 ident: pbac2e72bib54 article-title: A stochastic model for immunotherapy of cancer publication-title: Sci. Rep. doi: 10.1038/srep24169 – volume: 21 start-page: 3301 year: 2020 ident: pbac2e72bib65 article-title: Time from self-detection of symptoms to seeking definitive care among cervical cancer patients publication-title: Asian Pac. J. Cancer Prev. doi: 10.31557/apjcp.2020.21.11.3301 – start-page: 273 year: 2021 ident: pbac2e72bib71 article-title: Monoclonal antibodies for cancer immunotherapy – volume: 14 year: 2019 ident: pbac2e72bib52 article-title: Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization publication-title: PLoS One doi: 10.1371/journal.pone.0224787 – volume: 2109 year: 2019 ident: pbac2e72bib82 article-title: Role of microbiome in modulating immune responses in cancer publication-title: Mediators Inflammation doi: 10.1155/2019/4107917 – volume: 442 start-page: 1 year: 2018 ident: pbac2e72bib41 article-title: Mathematical modeling of tumour-induced immunosuppression by myeloid-derived suppressor cells: implications for therapeutic targeting strategies publication-title: J. Theor. Biol. doi: 10.1016/j.jtbi.2018.01.006 – volume: 14 year: 2018 ident: pbac2e72bib48 article-title: A mathematical model for IL-6-mediated, stem cell driven tumour growth and targeted treatment publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1005920 – volume: 10 start-page: 1528 year: 2021 ident: pbac2e72bib91 article-title: Cancer stem cells: what do we know about them? publication-title: Cells doi: 10.3390/cells10061528 – volume: 18 year: 2021 ident: pbac2e72bib4 article-title: Temporal order of mutations influences cancer initiation dynamics publication-title: Phys. Biol. doi: 10.1088/1478-3975/ac0b7e – start-page: 191 year: 2017 ident: pbac2e72bib60 article-title: Stochastic collocation methods for differential equations with white noise – volume: 27 start-page: 571 year: 2020 ident: pbac2e72bib16 article-title: Preferences for immunotherapy in melanoma: a systematic review publication-title: Ann. Surg. Oncol. doi: 10.1245/s10434-019-07963-y – volume: 19 start-page: 26 year: 2021 ident: pbac2e72bib69 article-title: EPHA7 mutation as a predictive biomarker for immune checkpoint inhibitors in multiple cancers publication-title: BMC Med. doi: 10.1186/s12916-020-01899-x – volume: 10 start-page: 764 year: 2020 ident: pbac2e72bib64 article-title: EMT, MET, plasticity, and tumour metastasis publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2020.07.003 – volume: 10 start-page: 9063 year: 2020 ident: pbac2e72bib36 article-title: A QSP model of prostate cancer immunotherapy to identify effective combination therapies publication-title: Sci. Rep. doi: 10.1038/s41598-020-65590-0 – volume: 7 start-page: a026781 year: 2017 ident: pbac2e72bib63 article-title: Tumour microenvironment and differential responses to therapy publication-title: Cold Spring Harbor Perspect. Med. doi: 10.1101/cshperspect.a026781 – year: 2021 ident: pbac2e72bib33 article-title: The role of dendritic cells in cancer and anti-tumour immunity publication-title: Semin. Immunol. doi: 10.1016/j.smim.2021.101481 – volume: 27 start-page: 87 year: 2020 ident: pbac2e72bib12 article-title: A review of cancer immunotherapy: from the past, to the present, to the future publication-title: Curr. Oncol. doi: 10.3747/co.27.5223 – volume: 19 start-page: 183 year: 2019 ident: pbac2e72bib7 article-title: The mechanics of tumour formation publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-019-0124-x – volume: 11 year: 2021 ident: pbac2e72bib85 article-title: Prognostic value of deep learning-mediated treatment monitoring in lung cancer patients receiving immunotherapy publication-title: Front. Oncol. doi: 10.3389/fonc.2021.609054 – start-page: 367 year: 2013 ident: pbac2e72bib39 article-title: A mathematical model of gene therapy for the treatment of cancer – volume: 1129 start-page: 539 year: 2009 ident: pbac2e72bib53 article-title: Cancer growth dynamics: stochastic models and noise induced effects publication-title: AIP Conf. Proc. doi: 10.1063/1.3140529 – volume: 12 start-page: 3130 year: 2021 ident: pbac2e72bib72 article-title: Intelligent stimuli-responsive nano immunomodulators for cancer immunotherapy publication-title: Chem. Sci. doi: 10.1039/d0sc06557a – volume: 61 start-page: 14 year: 2013 ident: pbac2e72bib50 article-title: Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy publication-title: Curr. Protoc. Pharmacol. doi: 10.1002/0471141755.ph1425s61 – volume: 8 start-page: 720 year: 2019 ident: pbac2e72bib26 article-title: A review of mathematical models for tumour dynamics and treatment resistance evolution of solid tumours publication-title: CPT: Pharmacometrics Syst. Pharmacol. doi: 10.1002/psp4.12450 – volume: 17 start-page: 1215 year: 2021 ident: pbac2e72bib22 article-title: Advances in liver cancer stem cell isolation and their characterization publication-title: Stem Cell Rev. Rep. doi: 10.1007/s12015-020-10114-6 – volume: 41 start-page: 1625 year: 2020 ident: pbac2e72bib6 article-title: DNA damage and mitochondria in cancer and aging publication-title: Carcinogenesis doi: 10.1093/carcin/bgaa114 – volume: 131 year: 2021 ident: pbac2e72bib32 article-title: Distinct mechanisms govern populations of myeloid-derived suppressor cells in chronic viral infection and cancer publication-title: J. Clin. Invest. doi: 10.1172/jci145971 – volume: 318 year: 2019 ident: pbac2e72bib42 article-title: Mathematical modelling of cancer stem cell-targeted immunotherapy publication-title: Math. Biosci. doi: 10.1016/j.mbs.2019.108269 – volume: 8 start-page: 1027 year: 2018 ident: pbac2e72bib28 article-title: Noise-induced bistability in the fate of cancer phenotypic quasispecies: a bit-strings approach publication-title: Sci. Rep. doi: 10.1038/s41598-018-19552-2 – volume: 15 start-page: 790 year: 2021 ident: pbac2e72bib3 article-title: Physical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms publication-title: Mol. Oncol. doi: 10.1002/1878-0261.12772 – volume: 65 year: 2020 ident: pbac2e72bib13 article-title: Computational modelling of modern cancer immunotherapy publication-title: Phys. Med. Biol. doi: 10.1088/1361-6560/abc3fc – volume: 38 start-page: 381 year: 2015 ident: pbac2e72bib75 article-title: Metabolism in embryonic and cancer stemness publication-title: Arch. Pharmacal Res. doi: 10.1007/s12272-015-0558-y – volume: 95 start-page: S2 year: 2016 ident: pbac2e72bib76 article-title: Cancer stem cells: understanding tumour hierarchy and heterogeneity publication-title: Medicine doi: 10.1097/md.0000000000004764 – volume: 438 start-page: 126 year: 2018 ident: pbac2e72bib15 article-title: Emerging microRNAs in cancer diagnosis, progression, and immune surveillance publication-title: Cancer Lett. doi: 10.1016/j.canlet.2018.09.019 – volume: 13 start-page: 21 year: 2013 ident: pbac2e72bib55 article-title: Spatio-temporal behaviour of the deep chlorophyll maximum in Mediterranean Sea: development of a stochastic model for picophytoplankton dynamics publication-title: Ecol. Complex. doi: 10.1016/j.ecocom.2012.10.002 – volume: 70 start-page: 223 year: 1998 ident: pbac2e72bib95 article-title: Stochastic resonance publication-title: Rev. Mod. Phys. doi: 10.1103/revmodphys.70.223 – volume: 13 start-page: 1660 year: 2020 ident: pbac2e72bib9 article-title: Cancer therapy: attempt cure or manage drug resistance? publication-title: Evol. Appl. doi: 10.1111/eva.12994 – volume: 31 start-page: 2150088 year: 2021 ident: pbac2e72bib38 article-title: Stochastic simulation on a minimal model of cancer immunoediting theory publication-title: Int. J. Bifurcation Chaos doi: 10.1142/s0218127421500887 – volume: 17 start-page: 1 year: 2021 ident: pbac2e72bib14 article-title: Immunotherapy and radiotherapy in melanoma: a multidisciplinary comprehensive review publication-title: Hum. Vaccines Immunother. doi: 10.1080/21645515.2021.1903827 – volume: 8 start-page: 9852 year: 2018 ident: pbac2e72bib99 article-title: Uhlmann curvature in dissipative phase transitions publication-title: Sci. Rep. doi: 10.1038/s41598-018-27362-9 – volume: 9 start-page: 84 year: 2020 ident: pbac2e72bib62 article-title: Tumour angiogenesis and anti-angiogenic strategies for cancer treatment publication-title: J. Clin. Med. doi: 10.3390/jcm9010084 – volume: 14 start-page: 2247 year: 2002 ident: pbac2e72bib98 article-title: Noise-induced effects in population dynamics publication-title: J. Phys.: Condens. Matter doi: 10.1088/0953-8984/14/9/313 – volume: 234 year: 2019 ident: pbac2e72bib51 article-title: Cancer stem cell (CSC) resistance drivers publication-title: Life Sci doi: 10.1016/j.lfs.2019.116781 – volume: 7 start-page: 79 year: 2020 ident: pbac2e72bib24 article-title: Cancer stem cell plasticity–a deadly deal publication-title: Front. Mol. Biosci. doi: 10.3389/fmolb.2020.00079 – volume: 13 start-page: 376 year: 2021 ident: pbac2e72bib49 article-title: Cancer stem cells-key players in tumour relapse publication-title: Cancers doi: 10.3390/cancers13030376 – volume: 53 start-page: 11 year: 2021 ident: pbac2e72bib86 article-title: The association between tumour mutational burden and prognosis is dependent on treatment context publication-title: Nat. Genet. doi: 10.1038/s41588-020-00752-4 – volume: 155 start-page: 62 year: 2021 ident: pbac2e72bib61 article-title: Free boundary limit of a tumour growth model with nutrient publication-title: J. Math. Pures Appl. doi: 10.1016/j.matpur.2021.01.007 – volume: 1 start-page: 36 year: 2017 ident: pbac2e72bib67 article-title: The potential of liquid biopsies for the early detection of cancer publication-title: npj Precis. Oncol. doi: 10.1038/s41698-017-0039-5 – year: 2016 ident: pbac2e72bib10 – volume: 40 start-page: 273 year: 2004 ident: pbac2e72bib97 article-title: Enhancement of stability in randomly switching potential with metastable state publication-title: Eur. Phys. J. B doi: 10.1140/epjb/e2004-00268-8 – volume: 204 start-page: 345 year: 2007 ident: pbac2e72bib44 article-title: In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumour publication-title: J. Exp. Med. doi: 10.1084/jem.20061890 – volume: 38 start-page: 3 year: 2021 ident: pbac2e72bib8 article-title: Steps in metastasis: an updated review publication-title: Med. Oncol. doi: 10.1007/s12032-020-01447-w – volume: 12 start-page: 128 year: 2021 ident: pbac2e72bib88 article-title: CellBox: interpretable machine learning for perturbation biology with application to the design of cancer combination therapy publication-title: Cell Syst. doi: 10.1016/j.cels.2020.11.013 – volume: 11 start-page: 1180 year: 2020 ident: pbac2e72bib93 article-title: Cancer stem cells—origins and biomarkers: perspectives for targeted personalized therapies publication-title: Front. Immunol. doi: 10.3389/fimmu.2020.01280 – volume: 6 start-page: 775 year: 2020 ident: pbac2e72bib19 article-title: Emerging mechanisms by which EMT programs control stemness publication-title: Trends Cancer doi: 10.1016/j.trecan.2020.03.011 – volume: 77 start-page: 1745 year: 2020 ident: pbac2e72bib94 article-title: Tumour angiogenesis: causes, consequences, challenges and opportunities publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-019-03351-7 |
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