An integrative model of cancer cell differentiation with immunotherapy

In order to improve cancer treatments, cancer cell differentiation and immunotherapy are the subjects of several studies in different branches of interdisciplinary sciences. In this work, we develop a new population model that integrates other complementary ones, thus emphasizing the relationship be...

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Published inPhysical biology Vol. 18; no. 6; p. 66007
Main Authors Margarit, David H, González, Nadia S, Romanelli, Lilia M, Fendrik, Alejandro J, Scagliotti, Ariel F, Reale, Marcela V
Format Journal Article
LanguageEnglish
Published England 01.11.2021
Subjects
Cell Differentiation
Humans
Immunotherapy
Neoplasms - therapy
Neoplastic Stem Cells
dynamical systems
mathematical modelling
cancer cell differentiation
cancer immunotherapy
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Summary:In order to improve cancer treatments, cancer cell differentiation and immunotherapy are the subjects of several studies in different branches of interdisciplinary sciences. In this work, we develop a new population model that integrates other complementary ones, thus emphasizing the relationship between cancer cells at different differentiation stages and the main immune system cells. For this new system, specific ranges were found where transdifferentiation of differentiated cancer cells can occur. In addition, a specific therapy against cancer stem cells was analysed by simulating cytotoxic cell vaccines. In reference to the latter, the different combinations of parameters that optimize it were studied.
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ISSN:1478-3967
1478-3975
DOI:10.1088/1478-3975/ac2e72