Gross Pathologic Types of Hepatocellular Carcinoma in Italy

The prevalence and independent predictors of the different macroscopic types of hepatocellular carcinoma (HCC) were assessed in 1,073 unselected patients of 14 hospitals in Italy from May 1996 to May 1997. Solitary HCC was the most common cancer type (44.6%), followed by multinodular (44.2%), diffus...

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Published inOncology Vol. 56; no. 3; pp. 189 - 192
Main Authors Stroffolini, Tommaso, Andreone, Pietro, Andriulli, Angelo, Ascione, Antonio, Craxì, Antonio, Chiaramonte, Maria, Galante, Domenico, Manghisi, Onofrio Giuseppe, Mazzanti, Roberto, Medaglia, Cinzia, Pilleri, Giampaolo, Rapaccini, GianLudovico, Albanese, Maddalena, Taliani, Gloria, Tosti, MariaElena, Villa, Erica, Gasbarrini, Giovanni
Format Journal Article
LanguageEnglish
Published Basel, Switzerland Karger 01.04.1999
S. Karger AG
Subjects
Biological and medical sciences
Carcinoma, Hepatocellular - epidemiology
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - virology
Clinical Study
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hepatitis Antibodies - blood
Humans
Italy - epidemiology
Liver Neoplasms - epidemiology
Liver Neoplasms - pathology
Liver Neoplasms - virology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Logistic Models
Male
Medical sciences
Middle Aged
Prevalence
Tumors
Italy
Europe
Gross pathology
Hepatocellular carcinoma
Italy
Diffuse
Human
Multiple
Prevalence
Hepatic disease
Malignant tumor
Statistical study
Nodule
Pathology
Digestive diseases
Gross examination
Subtype
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Summary:The prevalence and independent predictors of the different macroscopic types of hepatocellular carcinoma (HCC) were assessed in 1,073 unselected patients of 14 hospitals in Italy from May 1996 to May 1997. Solitary HCC was the most common cancer type (44.6%), followed by multinodular (44.2%), diffuse (8.4%) and massive (2.8%) types. After adjustment for the influence of confounders by multiple logistic regression analysis, Child-Pugh grades B and C were found to be independent predictors of multinodular (odds ratio, OR, 2.0; 95% confidence interval (CI) = 1.5–2.6) and diffuse (OR 2.6; 95% CI = 1.6–4.4) HCC types. These findings indicate that the majority of HCC cases are not detected at a potentially treatable stage. Delayed detection of HCC is associated with a higher likelihood of the multinodular or diffuse gross pathologic type.
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ISSN:0030-2414
1423-0232
DOI:10.1159/000011963