A mild and efficient procedure for alpha-bromination of ketones using N-bromosuccinimide catalysed by ammonium acetate

Cyclic ketones reacted with N-bromosuccinimide (NBS) catalysed by NH4OAc in Et2O at 25degreesC to give the corresponding alpha-brominated ketones in good yields, while acyclic ketones were efficiently brominated in CCl4 at 80degreesC.

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 4; pp. 470 - 471
Main Authors Tanemura, K, Suzuki, T, Nishida, Y, Satsumabayashi, K, Horaguchi, T
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.02.2004
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
HALOGENATION
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Summary:Cyclic ketones reacted with N-bromosuccinimide (NBS) catalysed by NH4OAc in Et2O at 25degreesC to give the corresponding alpha-brominated ketones in good yields, while acyclic ketones were efficiently brominated in CCl4 at 80degreesC.
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ISSN:1359-7345
1364-548X
DOI:10.1039/b315340a