Synthesis and reactions of partially reduced biisoquinolines

An improved synthesis of the 1,1', 2,2', 3,3', 4,4'-octahydro-1,1'-biisoquinoline ring system is described. The reactivity of this system has been investigated, including the unusually high basicity of the parent compound and its N,N'-dimethyl derivative. The resolution...

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 1; no. 17; pp. 3038 - 3047
Main Authors Elliott, MC, Williams, E
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.09.2003
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ALPHA-AMINO-ACIDS
ASYMMETRIC-SYNTHESIS
LIGANDS
DERIVATIVES
N-ACYL
CATALYSTS
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Summary:An improved synthesis of the 1,1', 2,2', 3,3', 4,4'-octahydro-1,1'-biisoquinoline ring system is described. The reactivity of this system has been investigated, including the unusually high basicity of the parent compound and its N,N'-dimethyl derivative. The resolution of the parent compound has been achieved for the first time, along with the development of a straightforward method for assaying its enantiomeric purity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1477-0520
1477-0539
DOI:10.1039/b306159k