The role of inflammation in age-related macular degeneration

Age-related macular degeneration (AMD) is a complex, chronic, and progressive disease which affects the macular area, being one of the leading causes of irreversible vision loss worldwide. Specific alterations of retinal structure occur at the macular level, which regarding its severity can range fr...

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Published inJournal of Mind and Medical Sciences Vol. 10; no. 2; pp. COV9 - 259
Main Authors Tricorache, Diana Florina, Dascalu, Ana Maria, Serboiu, Crenguta, Bobirca, Anca, Cretoiu, Dragos, Bratu, Dan, Tudor, Corneliu, Tribus, Laura Carina
Format Journal Article
LanguageEnglish
Published The Lutheran University Association, Inc., dba Valparaiso University 01.10.2023
Ion Motofei, Carol Davila University
Subjects
age-related
Demographic aspects
Development and progression
Inflammation
Macular degeneration
Physiological aspects
retinal pigment epithelium
Romania
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Summary:Age-related macular degeneration (AMD) is a complex, chronic, and progressive disease which affects the macular area, being one of the leading causes of irreversible vision loss worldwide. Specific alterations of retinal structure occur at the macular level, which regarding its severity can range from the presence of drusen to the development of geographic atrophy or choroidal neovascularization. AMD has long been considered a degenerative disease, but new studies highlight the role of inflammation present both in the atrophic form and in the exudative form. The present review is based on comprehensive research on PubMed and Web of Science databases, and it aims to describe the inflammatory pathways involved in AMD onset and progression. Understanding the molecules involved in AMD pathogenesis, and their mechanism of action, is crucial because they can be both biomarkers with a predictive role in disease management, as well as potential therapeutic targets. Keywords: inflammation, age-related, macular degeneration, retinal pigment epithelium
ISSN:2392-7674
2392-7674
DOI:10.22543/2392-7674.1421