Preliminary radiogenomic study of hepatitis B virus-related hepatocellular carcinoma: associations between MRI features and mutations

• Published in: Personalized medicine Vol. 20; no. 3; p. 215
• Main Authors: Gao, Shanshan, Wang, Feihang, Sun, Wei, Qian, Xianling, Ji, Yuan, Cheng, Yunfeng, Wang, Xiaolin, Liu, Lingxiao, Sheng, Ruofan, Zeng, Mengsu
• Format: Journal Article
• Language: English
• Published: England 01.05.2023
• Subjects: Carcinoma, Hepatocellular - diagnostic imaging; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Hepatitis B - complications; Hepatitis B - genetics; Hepatitis B virus - genetics; Humans; Liver Neoplasms - complications; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - genetics; Mutation - genetics; mutation; radiogenomics; MRI; hepatitis B virus; hepatocellular carcinoma
• ISSN: 1744-828X
• DOI: 10.2217/pme-2022-0093

To investigate associations between MRI features and high-frequency mutations of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). This study included 58 HCC patients who underwent contrast-enhanced MRI prior to surgical resection and genome sequencing. MRI features and mutation information were evaluated. The top five most frequently mutated genes in HCC were (53.45%), (24.14%), (22.41%), (18.97%) and  (17.24%). Mutations in and were associated with tumor necrosis (p = 0.035) and mosaic architecture (p = 0.015), respectively. Mutations in were associated with mosaic architecture (p = 0.025) and necrosis (p = 0.010). This preliminary radiogenomics analysis showed associations between MRI features and high-frequency mutations in HBV-related HCCs.