Effect of low-flux and high-flux dialysis membrane on plasma concentrations of cardiac troponin I

• Published in: Biomarkers in medicine Vol. 15; no. 16; pp. 1479 - 1486
• Main Authors: Šavuk, Ana, Svaguša, Tomo, Trkulja, Vladimir, Radeljak, Andrea, Rudan, Diana, Kudumija, Boris, Doko, Slava, Kovačević, Lucija, Pezić, Mija M, Ćorić, Valentina, Matić, Ivica, Prkačin, Ingrid
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.11.2021
• Subjects: cardiac Troponin I; chronic kidney disease; hemodiafiltration; hemodialysis; high-flux membrane; low-flux membrane; hemodialysis; cardiac Troponin I; high-flux membrane; chronic kidney disease; low-flux membrane; hemodiafiltration
• ISSN: 1752-0363; 1752-0371
• DOI: 10.2217/bmm-2021-0149

Cardiac troponin I (cTnI) concentration stability during dialysis have not been fully elucidated. The aim is to evaluate the effect of a single dialysis session on plasma cTnI. From 122 consecutive anuric adult patients (75 [61.5%] men, age 27–86 years, median 67) on chronic hemodialysis blood samples for cTnI measurement were taken before and after a dialysis. Dialysis had no effect on high-flux membranes (geometric means ratio = 0.99, 0.94–1.05, df 119, t = -0.19, multiplicity adjusted p = 0.847), but cTnI levels were higher after dialysis in patients on low-flux membranes (geometric means ratio = 1.14, 1.02–1.27, df 119, t = 2.59, adjusted p = 0.021). Dialysis session using low-flux membranes might increase the plasma cTnI.