A Programmable Signaling Molecular Recognition Nanocavity Prepared by Molecular Imprinting and Post-Imprinting Modifications

• Published in: Angewandte Chemie Vol. 128; no. 42; pp. 13217 - 13221
• Main Authors: Horikawa, Ryo, Sunayama, Hirobumi, Kitayama, Yukiya, Takano, Eri, Takeuchi, Toshifumi
• Format: Journal Article
• Language: English; German
• Published: Weinheim Blackwell Publishing Ltd 10.10.2016; Wiley Subscription Services, Inc
• Subjects: Antibodies; Bearing; Chemistry; Conjugation; Construction; Construction sites; Emergence; Fabrication; Functional anatomy; Functional groups; Molecular imprinting; Molekulare Erkennung; Nanostructure; Polymere; Polymerization; Proteine; Prägung; Receptors; Recognition; Scaffolds; Sensoren; Strategy
• ISSN: 0044-8249; 1521-3757
• DOI: 10.1002/ange.201605992

Inspired by biosystems, a process is proposed for preparing next‐generation artificial polymer receptors with molecular recognition abilities capable of programmable site‐directed modification following construction of nanocavities to provide multi‐functionality. The proposed strategy involves strictly regulated multi‐step chemical modifications: 1) fabrication of scaffolds by molecular imprinting for use as molecular recognition fields possessing reactive sites for further modifications at pre‐determined positions, and 2) conjugation of appropriate functional groups with the reactive sites by post‐imprinting modifications to develop programmed functionalizations designed prior to polymerization, allowing independent introduction of multiple functional groups. The proposed strategy holds promise as a reliable, affordable, and versatile approach, facilitating the emergence of polymer‐based artificial antibodies bearing desirable functions that are beyond those of natural antibodies. Nach dem Vorbild posttranslationaler Modifikationen in der Proteinbiosynthese wurden künstliche Polymerrezeptoren mit der Fähigkeit zur molekularen Erkennung entwickelt. Der Prozess umfasst die Herstellung reaktiver Zentren in Nanokavitäten, die eine programmierbare ortsgerichtete Multifunktionalisierung ermöglichen.