Association between the 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene and sudden sensorineural hearing loss in Caucasian population: a meta-analysis

• Published in: European archives of oto-rhino-laryngology Vol. 278; no. 7; pp. 2203 - 2208
• Main Authors: Wei, Zhenxing, Chang, Kunpeng, Fan, Chongsheng
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2021
• Subjects: Genetic Predisposition to Disease; Genotype; Head and Neck Surgery; Hearing Loss, Sensorineural - genetics; Humans; Medicine; Medicine & Public Health; Neurosurgery; Odds Ratio; Otorhinolaryngology; Plasminogen Activator Inhibitor 1 - genetics; Polymorphism, Genetic; Review Article; Risk Factors; Plasminogen activator inhibitor-1 (PAI-1); Sudden sensorineural hearing loss; 4G/5G polymorphism; Caucasian population; Meta-analysis
• ISSN: 0937-4477; 1434-4726; 1434-4726
• DOI: 10.1007/s00405-020-06305-z

Purpose To clarify the association between the 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) and sudden sensorineural hearing loss (SSNHL). Methods A systematic literature search of related studies up to August 30, 2019 in the PubMed and Embase databases was performed, and the results were displayed by odds ratios (ORs), and their 95% confidence intervals (CIs) were assessed using the STATA12.0 software using an allele model and a recessive model. Results Three eligible studies covering 519 subjects (241 cases, 278 controls) were identified. No statistically significant association was detected between the 4G/5G polymorphism and SSNHL in any model (allele model: 5G vs. 4G, OR = 0.952, 95% CI = 0.765–1.185, P  = 0.662; recessive model: 5G/5G vs. 4G/5G + 4G/4G, OR = 0.841, 95% CI = 0.415–1.704, P  = 0.631). Conclusions There is no statistically significant association between the 4G/5G polymorphism of PAI-1 gene and SSNHL in the Caucasian population, and well-designed studies covering more patients and institutions should be conducted.