Expeditious Synthesis and Spectroscopic Characterization of 2-Methyl-3-substituted-quinazolin-4(3H)-one Derivatives

Quinazoline and quinazolinone derivatives are well-known bioactive heterocycles owing to their therapeutic diversity and extensive medicinal application in drug design and pharmaceutics. A series of 2-methyl-3-substituted quinazolin-4(3H)-one derivatives 8a-q was herein synthesized from synthetic co...

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Bibliographic Details
Published inOriental journal of chemistry Vol. 33; no. 2; pp. 562 - 574
Main Authors Ajani, Olayinka O, Audu, Oluwatosin Y, Germann, Markus W, Bello, Babatunde L
Format Journal Article
LanguageEnglish
Published Bhopal Oriental Scientific Publishing Company 01.01.2017
Subjects
Chemical synthesis
Chemistry
Derivatives
Iridium
Mathematical analysis
NMR
Nuclear magnetic resonance
Organic chemistry
Pharmaceutical industry
Substitutes
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Summary:Quinazoline and quinazolinone derivatives are well-known bioactive heterocycles owing to their therapeutic diversity and extensive medicinal application in drug design and pharmaceutics. A series of 2-methyl-3-substituted quinazolin-4(3H)-one derivatives 8a-q was herein synthesized from synthetic conversion of anthranilic acid to 2-methyl-4H-3,1-benzoxazi-4-one, 7 which was subsequently transformed to the targeted 2,3-disubstituted quinazolin-4(3H)-one derivatives 8a-q by reacting with some notable amino-containing moieties via an ameliorable pathway. The catalyst-free synthesis was successful achieved by careful reaction optimization study using solvent choice and reaction temperature variability as key parameters. The chemical structures of the synthesized compounds were confirmed by IR, UV, 1H-NMR, 13C-NMR and DEPT-135 as well as analytical data.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/330203