The rat model in the comparative evaluation of anthracyclines cardiotoxicity

In the present investigation, the cardiotoxic effects of three anthracycline analogs (doxorubicin, 4'-epi-doxorubicin and 4'-deoxy-doxorubicin) were compared. For this purpose, 9.0 mg/kg of doxorubicin, divided into three closely spaced subdoses, were injected intravenously in rats. The tw...

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Bibliographic Details
Published inTumori Vol. 75; no. 6; p. 533
Main Authors Lanza, E, Rozza, A, Favalli, L, Monti, E, Poggi, P, Villani, F
Format Journal Article
LanguageEnglish
Published United States 31.12.1989
Subjects
Animals
Antibiotics, Antineoplastic - toxicity
Doxorubicin - analogs & derivatives
Doxorubicin - toxicity
Electrocardiography
Epirubicin - toxicity
Female
Heart Diseases - chemically induced
Heart Diseases - pathology
Heart Diseases - physiopathology
Myocardium - pathology
Organ Size
Rats
Rats, Inbred Strains
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Summary:In the present investigation, the cardiotoxic effects of three anthracycline analogs (doxorubicin, 4'-epi-doxorubicin and 4'-deoxy-doxorubicin) were compared. For this purpose, 9.0 mg/kg of doxorubicin, divided into three closely spaced subdoses, were injected intravenously in rats. The two derivatives were administered according to the same time schedule and their doses were chosen on the basis of the clinically adopted ratio, doxorubicin: 4'-epidoxorubicin: 4'-deoxy-doxorubicin = 1:1:0.5. The degree of cardiomyopathy induced by the three anthracyclines was evaluated by ECG changes and morphological alterations. Doxorubicin was found to produce a significant degree of cardiotoxicity, thus confirming the validity of the experimental model adopted. Both 4'-substituted derivatives proved to be less cardiotoxic than the parent compound, although not completely devoid of this side effect.
ISSN:0300-8916
DOI:10.1177/030089168907500603