Intraoperative crystalloid-colloid infusion ratio associated with the development of early surgical complications after ileal pouch-anal anastomosis in ulcerative colitis: a multicenter long-term follow-up study

• Published in: International journal of colorectal disease Vol. 38; no. 1; p. 15
• Main Authors: Xu, Weimin, Yang, Yiqing, Hua, Zhebin, Wang, Yaosheng, Ding, Wenjun, Lian, Lei, Cui, Long, Wu, Xiaojian, Ding, Zhao, Du, Peng, Ye, Hairong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 17.01.2023
• Subjects: Anastomosis, Surgical - adverse effects; Colitis, Ulcerative - complications; Colitis, Ulcerative - surgery; Colonic Pouches - adverse effects; Crystalloid Solutions; Follow-Up Studies; Gastroenterology; Hepatology; Humans; Internal Medicine; Medicine; Medicine & Public Health; Postoperative Complications - etiology; Postoperative Complications - surgery; Proctocolectomy, Restorative - adverse effects; Proctology; Retrospective Studies; Surgery; Treatment Outcome; Surgical complications; Ileal pouch-anal anastomosis; Ulcerative colitis; Intraoperative crystalloid-colloid infusion
• ISSN: 1432-1262; 1432-1262
• DOI: 10.1007/s00384-023-04309-9

Background Intraoperative intravenous fluid administration proves to be associated with surgical patients’ postoperative outcomes. Few studies reported the relationship between intraoperative crystalloid-colloid infusion ratio and early surgical complications after ileal pouch-anal anastomosis (IPAA) in ulcerative colitis (UC). Methods Data on patients with underwent IPAA from January 2008 to March 2022 at our three inflammatory bowel disease (IBD) surgery centers were retrospectively collected. Intraoperative anesthetic data were recorded and later evaluated by our team anesthesiologist. Results A total of 140 eligible patients with a median follow-up time of 6.0 years [interquartile range (IQR): 2.0–8.0] were enrolled. Among all enrolled patients, 34 (24.3%) developed early surgical complications after IPAA. Greater blood loss and lower crystalloid-colloid infusion ratio were observed in patients with early surgical complications. Crystalloid-colloid infusion ratio < 2 and blood loss ≥ 200 ml had the most significant area under the receiver-operating characteristic curve (AUC) of 0.664 and 0.674 in predicting early surgical complications. Crystalloid-colloid infusion ratio < 2 [odds ratio (OR), 2.571; 95% confidence intervals (CI), 1.067–6.195, p  = 0.035] and blood loss ≥ 200 ml (OR, 3.165; 95% CI, 1.288–7.777, p  = 0.012) were independent risk factors for the development of early post-IPAA complications. Conclusion Intraoperative crystalloid-colloid infusion ratio < 2 and blood loss volume over 200 ml during IPAA contribute to the occurrence of early surgical complications. Early attentions and necessary interventions are warranted to avoid these risk factors during the IPAA surgery in order to prevent the development of early surgical complications.