Relationship between doxorubicin-induced ECG changes and myocardial alterations in rats

The aim of the present study was to evaluate the dose- and time-dependence of the effect displayed by doxorubicin (DXR) on the electrocardiogram (ECG) and to establish the relationship between structural alterations of the myocardium and ECG changes in rats administered DXR, at a dose of 1.5 or 3.0...

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Bibliographic Details
Published inTumori Vol. 72; no. 3; p. 323
Main Authors Villani, F, Monti, E, Piccinini, F, Favalli, L, Lanza, E, Rozza Dionigi, A, Poggi, P
Format Journal Article
LanguageEnglish
Published United States 30.06.1986
Subjects
Animals
Calcium - blood
Cardiomyopathies - chemically induced
Doxorubicin - administration & dosage
Doxorubicin - adverse effects
Electrocardiography
Female
Heart - drug effects
Myocardium - pathology
Potassium - blood
Rats
Rats, Inbred Strains
Time Factors
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Summary:The aim of the present study was to evaluate the dose- and time-dependence of the effect displayed by doxorubicin (DXR) on the electrocardiogram (ECG) and to establish the relationship between structural alterations of the myocardium and ECG changes in rats administered DXR, at a dose of 1.5 or 3.0 mg/kg, every 3 days for a total of three administrations. The most interesting findings consisted of a dose-dependent, but reversible prolongation of the QRS complex, and in a dose-dependent and progressive irreversible increase in QaT and, in particular, in SaT duration. Furthermore, animals treated with the higher DXR dose showed a slight increase in serum K+ concentration and a significant decrease in serum Ca2+ levels. A good correlation was found between the morphologic score indicating the degree of observed tissue damage and SaT prolongation. These results therefore support the usefulness of measuring this ECG parameter for monitoring the development of DXR-induced cardiotoxicity in rats.
ISSN:0300-8916
DOI:10.1177/030089168607200315