Transient neonatal hypocalcemia, hypomagnesemia, and high serum parathyroid hormone with maternal hyperparathyroidism

Findings in a case of neonatal tetany in a child whose mother had elevated blood parathyroid hormone levels because of a parathyroid adenoma are given. The child was found to have hypocalcemia, hypomagnesemia, and hyperphosphatemia. Parathyroid hormone in the infant was found to be elevated. It has...

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Bibliographic Details
Published inAnnals of internal medicine Vol. 82; no. 5; p. 670
Main Authors Monteleone, J A, Lee, J B, Tashjian, Jr, A H, Cantor, H E
Format Journal Article
LanguageEnglish
Published United States 01.05.1975
Subjects
Adenoma - complications
Female
Humans
Hyperparathyroidism - complications
Hypocalcemia - etiology
Hypoparathyroidism - physiopathology
Infant, Newborn
Infant, Newborn, Diseases - etiology
Magnesium - blood
Maternal-Fetal Exchange
Parathyroid Hormone - blood
Parathyroid Neoplasms - complications
Pregnancy
Pregnancy Complications
Tetany - etiology
Time Factors
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Summary:Findings in a case of neonatal tetany in a child whose mother had elevated blood parathyroid hormone levels because of a parathyroid adenoma are given. The child was found to have hypocalcemia, hypomagnesemia, and hyperphosphatemia. Parathyroid hormone in the infant was found to be elevated. It has been postulated that the pathophysiologic mechanism of the hypocalcemia in this syndrome is transient hypoparathyroidism. The present case suggests a different mechanism: hypomagnesemia and end-organ refractoriness to parathyroid hormone, a state analogous to pseudohypoparathyroidism.
ISSN:0003-4819
DOI:10.7326/0003-4819-82-5-670