Impact of cytokines levels and interleukin 6 (-634 C>G) polymorphism on clinical outcomes in patients with sepsis

Sepsis is the leading cause of death in intensive care units (ICUs), despite increased research on inflammation and the use of new therapies. APACHE II and SOFA prognostic scores, serum levels of certain cytokines, and IL6 (-634 C>G) polymorphisms were evaluated, in association with sepsis and mo...

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Published inMeta Gene Vol. 26; p. 100814
Main Authors de Oliveira Filho, Romério Alencar, Monteiro Júnior, José Gildo de Moura, Sobral Filho, Dário Celestino, Torres, Dilênia de Oliveira Cipriano, Souto, Fabrício Oliveira, Martins, Danyelly Bruneska Gondim, de Lima Filho, José Luiz, de Araújo, Rosângela Ferreira Frade
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.12.2020
Subjects
Cytokines
Interleukins
Polymorphism
Prognosis
Sepsis
Prognosis
IL
CBA
OR
Cytokines
CI
APACHE II
TNF
SOFA
IFN-γ
Interleukins
SNP
PROCAPE
Sepsis
ICU
PCR
RFLP
Polymorphism
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Summary:Sepsis is the leading cause of death in intensive care units (ICUs), despite increased research on inflammation and the use of new therapies. APACHE II and SOFA prognostic scores, serum levels of certain cytokines, and IL6 (-634 C>G) polymorphisms were evaluated, in association with sepsis and mortality. Overall, 120 patients (70 septic and 50 non-septic) admitted to the ICU of a cardiology hospital were included in this study. Serum cytokine levels were determined by cytometric bead array and IL6 polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism analysis. Among the 120 patients and in the group of patients with sepsis, interleukin (IL) 6 demonstrated the highest serum levels. Patients with sepsis showed higher APACHE II and SOFA and greatly elevated IL6 levels. Additionally, both scores were associated with mortality. IL6 polymorphism did not influence the serum levels of this cytokine, prognostic scores, or the risk of sepsis. IL6 levels were associated with sepsis, but a polymorphism minimally investigated in this context, IL6 (-634 C>G), did not influence the serum levels of this interleukin or the clinical outcomes of patients with sepsis. However, as this gene is extremely polymorphic, a broader association study of prognostic scores is needed, considering other polymorphisms.
ISSN:2214-5400
2214-5400
DOI:10.1016/j.mgene.2020.100814