The chemotherapy of prostatic adenocarcinoma

• Published in: Annals of internal medicine Vol. 92; no. 5; p. 681
• Main Authors: Torti, F M, Carter, S K
• Format: Journal Article
• Language: English
• Published: United States 01.05.1980
• Subjects: Acid Phosphatase - analysis; Adenocarcinoma - drug therapy; Adenocarcinoma - enzymology; Antineoplastic Agents - administration & dosage; Cisplatin - administration & dosage; Clinical Trials as Topic; Cyclophosphamide - administration & dosage; Doxorubicin - administration & dosage; Drug Therapy, Combination; Estramustine - administration & dosage; Fluorouracil - administration & dosage; Humans; Lomustine - administration & dosage; Male; Prednimustine - administration & dosage; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - enzymology
• ISSN: 0003-4819
• DOI: 10.7326/0003-4819-92-5-681

A number of chemotherapeutic agents show moderate promise for the palliative treatment of metastatic prostatic carcinoma. Although patterns of metastatic disease make classic response rates difficult to obtain and interpret, doxorubicin, cyclophosphamide, dacarbazine (DTIC), and cisplatin have activity in patients who have failed conventional hormonal treatment. In most studies, a survival advantage is seen for responders to these and other chemotherapeutic agents, but no survival advantage has been seen for the treatment cohorts when compared to groups not receiving chemotherapy. Therefore, estimates of the usefulness of these agents must be considered tentative. Multiple drug therapy has not yet shown definite superiority to single agent treatment. The uses and limitations of acid phosphatase as a tumor marker, as well as particular difficulties in measuring tumor response in the disease, are detailed herein.