Sialylation of cell surface glycoconjugates modulates cytosolic galectin-mediated responses upon organelle damage Minireview

Sialylation is an important terminal modification of glycoconjugates that mediate diverse functions in physiology and disease. In this review we focus on how altered cell surface sialylation status is sensed by cytosolic galectins when the integrity of intracellular vesicles or organelles is comprom...

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Published inGlycoconjugate journal Vol. 40; no. 3; pp. 295 - 303
Main Authors Weng, I-Chun, Chen, Hung-Lin, Lin, Wei-Han, Liu, Fu-Tong
Format Journal Article
LanguageEnglish
Published New York Springer US 01.06.2023
Subjects
Animals
Biochemistry
Biomedical and Life Sciences
Cytosol - metabolism
Galectins - metabolism
Glycoconjugates - metabolism
Life Sciences
Mammals - metabolism
Mini Review
Organelles
Pathology
Polysaccharides - metabolism
Galectin
Glycoconjugate
Sialidase
Organelle damage
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Summary:Sialylation is an important terminal modification of glycoconjugates that mediate diverse functions in physiology and disease. In this review we focus on how altered cell surface sialylation status is sensed by cytosolic galectins when the integrity of intracellular vesicles or organelles is compromised to expose luminal glycans to the cytosolic milieu, and how this impacts galectin-mediated cellular responses. In addition, we discuss the roles of mammalian sialidases on the cell surface, in the organelle lumen and cytosol, and raise the possibility that intracellular glycan processing may be critical in controlling various galectin-mediated responses when cells encounter stress.
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ISSN:0282-0080
1573-4986
1573-4986
DOI:10.1007/s10719-023-10112-z