Study on Leakage of Sesame (Sesamum indicum L.) and Coconut (Cocos nucifera L.) Liposomes

Leakage phenomena on sesame (Sesamum indicum L.) and coconut (Cocos nucifera L.) liposomes has been studied to evaluate their ability as drug delivery materials. Permeation of carboxyfluorescein through the liposomes with and without added cholesterol was examined. Sesame liposomes release carboxyfl...

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Published inOriental journal of chemistry Vol. 31; no. 1; pp. 435 - 439
Main Authors Hudiyanti, Dwi, Raharjo, Tri, Narsito, Narsito, Noegrohati, Sri
Format Journal Article
LanguageEnglish
Published Bhopal Oriental Scientific Publishing Company 01.01.2015
Subjects
Cholesterol
Drug delivery systems
Ingredients
Leakage
Liposomes
Nitrogen
Permeability
Soybeans
Thin films
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Summary:Leakage phenomena on sesame (Sesamum indicum L.) and coconut (Cocos nucifera L.) liposomes has been studied to evaluate their ability as drug delivery materials. Permeation of carboxyfluorescein through the liposomes with and without added cholesterol was examined. Sesame liposomes release carboxyfluorescein less than coconut liposomes in all circumstances. Sesame liposomes save about 50% of payload after 17 hours of storage while coconut liposomes only 10%. Addition of cholesterol has increase storage capability of all liposomes. The sesame-cholesterol and coconut-cholesterol liposomes save greater amount of payload compare to the original. Sesame liposomes have better potency as drug delivery systems.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/310152