Gelatin-lecithin-F127 gel mediated self-assembly of curcumin vesicles for enhanced wound healing

Curcumin, a principal component of Curcuma longa, has a long history of being used topically for wound healing. However, poor aqueous solubility of curcumin leads to poor topical absorption. Recently, gelatin based gel has been reported to overcome this issue. However, the release of curcumin from g...

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Bibliographic Details
Published inInternational journal of biological macromolecules Vol. 210; pp. 403 - 414
Main Authors Das, Ram Pada, Gandhi, Vishwa V., Verma, Gunjan, Ajish, Juby K., Singh, Beena G., Kunwar, Amit
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.06.2022
Subjects
Curcumin
Gelatin
Gelation
Nanovesicles
Rheology
Wound healing
Curcumin
Wound healing
Gelatin
Rheology
Gelation
Nanovesicles
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Summary:Curcumin, a principal component of Curcuma longa, has a long history of being used topically for wound healing. However, poor aqueous solubility of curcumin leads to poor topical absorption. Recently, gelatin based gel has been reported to overcome this issue. However, the release of curcumin from gelatin gel in the bioavailable or easily absorbable form is still a challenge. The present study reports the development of a composite gel prepared from gelatin, F127 and lecithin using temperature dependant gelation and loading of curcumin within it. Notably, the composite gel facilitated the release of curcumin entrapped within vesicles of ~400 nm size. Further, the composite gel exhibited increase in the storage modulus or gel strength, stability, pore size and hydrophobicity as compared to only gelatin gel. Finally, wound healing assay in murine model indicated that curcumin delivered through composite gel showed a significantly faster healing as compared to that delivered through organic solvent. This was also validated by histopathological and biochemical analysis showing better epithelization and collagen synthesis in the group dressed with curcumin containing composite gel. In conclusion, composite gel facilitated the release of bioavailable or easily absorbable curcumin which in turn enhanced the wound healing. [Display omitted] •Mixture of gelatin, F127 and lecithin exhibited temperature-dependent gelation.•Composite gel comprising gelatin, F127 and lecithin proposed for curcumin entrapment•Composite gel released curcumin entrapped within nanovesicles•Curcumin delivered through composite gel accelerated wound healing•Curcumin delivered through composite gel induced collagen synthesis
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ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2022.04.134