Observation of lymphadenopathy, systemic symptoms, and treatment in suspected indolent cutaneous B-cell lymphomas

• Published in: Archives of dermatological research Vol. 316; no. 5; p. 199
• Main Authors: Puccio, Jordyn, Huang, Ying, Viveiros, Matthew D., Reneau, John C., Chung, Catherine, Spaccarelli, Natalie, Dulmage, Brittany
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 22.05.2024
• Subjects: Adult; Aged; Aged, 80 and over; Biopsy; Dermatology; Female; Humans; Lymph Nodes - pathology; Lymphadenopathy - diagnosis; Lymphadenopathy - pathology; Lymphoma, B-Cell, Marginal Zone - diagnosis; Lymphoma, B-Cell, Marginal Zone - pathology; Lymphoma, B-Cell, Marginal Zone - therapy; Lymphoma, Follicular - diagnosis; Lymphoma, Follicular - drug therapy; Lymphoma, Follicular - pathology; Lymphoma, Follicular - therapy; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Staging; Research Letter; Retrospective Studies; Skin - pathology; Skin Neoplasms - diagnosis; Skin Neoplasms - pathology; Skin Neoplasms - therapy; Oncodermatology; Oncology; Clinical research; Treatment options; Surgery
• ISSN: 1432-069X; 1432-069X
• DOI: 10.1007/s00403-024-02902-8

Background Following the initial diagnosis of a marginal zone or follicle center lymphoma on skin biopsy, patients undergo staging to determine the extent of disease. Objective We sought to characterize the frequency that these patients were found to have a systemic nodal disease upon work-up as well as the impact of imaging on disease management. Methods We conducted a retrospective chart review of patients presenting with a working diagnosis of PCMZL or PCFCL treated at The Ohio State University from 1990 to 2022. Data collected included: patient history, progress notes, virtual encounters, laboratory results, presentation features, imaging, and pathology. Biomarkers included ANA, SSA/SSB, BCL6 and H. Pylori labs, bone marrow biopsies, positive imaging, and need of systemic medication and mortality. Results 71 patients with suspected PCMZL and PCFCL were identified. 66 of 71 patients underwent imaging. Of this group, 12 patients (9 with suspected PCFCL and 3 with suspected PCMZL) demonstrated lymphadenopathy on imaging. Of these 12 patients, 5 underwent biopsy of suspected lymph nodes, and 3 had biopsy-proven nodal involvement and received systemic therapy. Of the remaining 7 patients with evidence of lymphadenopathy on imaging, 4 were thought to have reactive lymph nodes, and 3 were treated empirically with systemic chemotherapy due to the extent or progression of their disease. Of patients with imaging negative for lymphadenopathy, 3 of 52 (5.8%) patients with received systemic treatment, while 49 of 52 patients (94.2%) received localized treatment. Limitations Most of the relationships between this data were correlational and patients selected for this study were limited to a single institution. Conclusion Prospective study of the role of imaging without subsequent lymph biopsy to direct treatment decisions is warranted.