Localization and ordering of acid alpha-glucosidase (GAA) and thymidine kinase (TK1) by fluorescence in situ hybridization

Genomic DNA clones of human acid alpha glucosidase (GAA) and thymidine kinase (TK1) were used to map the exact location and order of these genes on human chromosome 17. Both genes were localized to the 17q25-qter band (17q25.2-q25.3), with GAA distal to TK1. They were also shown to be, respectively,...

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Published inHuman genetics Vol. 97; no. 3; p. 404
Main Authors Kuo, W L, Hirschhorn, R, Huie, M L, Hirschhorn, K
Format Journal Article
LanguageEnglish
Published Germany 01.03.1996
Subjects
Chromosome Mapping
Chromosomes, Human, Pair 17 - genetics
Glucosidases - genetics
Humans
In Situ Hybridization, Fluorescence
Thymidine Kinase - genetics
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Summary:Genomic DNA clones of human acid alpha glucosidase (GAA) and thymidine kinase (TK1) were used to map the exact location and order of these genes on human chromosome 17. Both genes were localized to the 17q25-qter band (17q25.2-q25.3), with GAA distal to TK1. They were also shown to be, respectively, distal and proximal to an anonymous cosmid (cK17.71) previously mapped to this region.
ISSN:0340-6717
DOI:10.1007/BF02185782