Effect of consumption of anthocyanin-rich products on NMR lipoprotein subclasses and biomarkers in hypercholesterolemic subjects: a randomized controlled trial (the AppleCOR study)

• Published in: Food & function Vol. 16; no. 6; pp. 2279 - 229
• Main Authors: Pedret, A, Llauradó, E, Calderón-Pérez, L, Companys, J, Pla-Pagà, L, Salamanca, P, Sandoval-Ramírez, B. A, Besora-Moreno, M, Catalán, Ú, Fernández-Castillejo, S, Ludwig, I, Macià, A, Rubió-Piqué, L, Sampson, M, Remaley, A. T, Valls, R. M, Motilva, M. J, Solà, R
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 17.03.2025
• Subjects: Adult; Aged; Alanine; Anthocyanins; Anthocyanins - administration & dosage; Anthocyanins - metabolism; Apples; Biomarkers; Biomarkers - blood; Female; Fruit - chemistry; Fruit - metabolism; High density lipoprotein; Humans; Hypercholesterolemia - blood; Hypercholesterolemia - diet therapy; Hypercholesterolemia - metabolism; Lipoproteins - blood; Lipoproteins - metabolism; Low density lipoprotein; Magnetic Resonance Spectroscopy; Male; Malus - chemistry; Malus - metabolism; Metabolites; Middle Aged; NMR; Nuclear magnetic resonance
• ISSN: 2042-6496; 2042-650X; 2042-650X
• DOI: 10.1039/d4fo02949f

Our aim was to assess the effect of intake of anthocyanin biofortified red-fleshed apples (RFA) versus that of common white apples (WFA) without anthocyanins on the NMR lipoprotein subfraction profile and other NMR metabolites. Additionally, an aronia infusion (AI) arm, matching the anthocyanin cont...