Glutathione system of erythrocyte and plasma in peptic ulcer

• Published in: Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Vol. 3; no. 1; pp. 99 - 103
• Main Authors: Kulinsky, V. I., Shcherbatykh, A. V., Bolsheshapov, A. A., Bakhtairova, V. I., Bulavintseva, O. A., Egorova, I. E., Suslova, A. I., Yasko, M. V., Kolbaseeva, O. V., Noskova, L. K.
• Format: Journal Article
• Language: English
• Published: Dordrecht SP MAIK Nauka/Interperiodica 01.03.2009; Springer Nature B.V
• Subjects: Biochemistry; Bioorganic Chemistry; Chemistry; Chemistry and Materials Science; Clinical Studies; Erythrocytes; Medicinal Chemistry; Plasma; Ulcers; glutathione system; peptic ulcer; oxidative stress
• ISSN: 1990-7508; 1990-7516
• DOI: 10.1134/S1990750809010156

A complex study of the blood glutathione system has been carried out for the first time in patients with peptic (gastric and duodenal) ulcer. In erythrocytes and blood plasma of patients with the complicated peptic ulcer and postgastroresection syndromes there was the increase of conjugated dienes (and in the second group the increase in antioxidant activity). Under these conditions the main change was the sharp and identical decrease in glutathione peroxidase activity. In patients with uncomplicated peptic ulcer there was sharp increase in erythrocite and plasma glutathione reductase activity and plasma GSH. In operated but basically healthy patients plasma glutathione peroxidase remained decreased but plasma GSH sharply increased. Evidently complicated peptic ulcer is characterized by decreased functioning of the glutathione system. Activation of this system and the decrease or disappearance of manifestations of oxidative stress are associated with a favorable course of this disease, especially at uncomplicated peptic ulcer. The revealed changes significantly differ from those observed in patients with viral hepatitis, blle excretory diseases and strokes.