The efficacy of moxifloxacin in patients with bacterial keratitis

• Published in: Vojnosanitetski pregled Vol. 75; no. 2; pp. 206 - 212
• Main Authors: Janicijevic, Katarina, Kocic, Sanja, Radovanovic, Snezana, Radevic, Svetlana, Mihailjevic, Olgica, Janicijevic-Petrovic, Mirjana
• Format: Journal Article
• Language: English
• Published: Military Health Department, Ministry of Defance, Serbia 01.01.2018
• Subjects: bacterial keratitis; complications; moxifloxacin; placebo
• ISSN: 0042-8450; 2406-0720
• DOI: 10.2298/VSP160510284J

Background/Aim. Keratitis is a sociomedical problem of moderately developed countries. including Serbia, too. The incidence of bacterial keratitis in the world is about 20% in relation to all keratitis, but its frequency in Serbia is still not known. Bearing in mind the complications in the front segment of the eye after bacterial keratitis (ulcer, neovascularization, fibrosis) and decline in visual acuity, it was necessary to assess the efficacy of local therapy by moxifloxacin which will shorten the healing time and reduce complications. The aim of the study was to analyze the efficiency of shortening the treatment of bacterial keratitis with moxifloxacin. Methods. The study was designed as prospective, randomized, double-blind study. The study included 30 patients with diagnosed keratitis and locally applied antibiotic moxifloxacin, and 60 patients in a control group, with locally applied artificial tears. All participants were subjected to complete clinical ophthalmologic analysis (2015/16), for a period of 1?15 days after the application of therapies (healing time of corneal pathology). The following was determined in all patients: degree of hyperemia, degree of epithelial defect, level of corneal sensitivity, level of tear secretion and tear quality, degree of conjunctival secretion, degree of neovascularisation and corneal scarring, degree of visual acuity, score of subjective symptomatology and correlation of ophthalmological findings and subjective symptoms. Results. There was a statistically significant difference in times of therapeutic efficacy/clinical response between the study group patients who received moxifloxacin and the control group patients who received arteficial tears. Conclusion. Local application of moxifloxacin had therapeutic effect (total benefit) both in terms of the effective shortening of the healing time and also the reduction of the complications of bacterial keratitis, without unwanted effects. nema