A research review of experimental animal models with myelodysplastic syndrome

Myelodysplastic syndrome (MDS) consists of a group of hematologic tumors that are derived from the clonal proliferation of hematopoietic stem cells, featuring abnormal hematopoietic cell development and ineffective hematopoiesis. Animal models are an important scientific research platform that has b...

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Published inClinical & translational oncology Vol. 25; no. 1; pp. 105 - 113
Main Authors Chen, Gen-Wang, Chen, Mei-Na, Liu, Lei, Zheng, Yu-Yu, Wang, Jin-Peng, Gong, Si-Si, Huang, Rong-Fu, Fan, Chun-Mei, Chen, Yue-Zu
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.01.2023
Subjects
Animals
Disease Models, Animal
Hematologic Neoplasms
Hematopoiesis
Hematopoietic Stem Cells - pathology
Humans
Medicine
Medicine & Public Health
Mice
Myelodysplastic Syndromes - genetics
Oncology
Review Article
Myelodysplastic syndrome (MDS)
Animal model
Spontaneous MDS model
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Summary:Myelodysplastic syndrome (MDS) consists of a group of hematologic tumors that are derived from the clonal proliferation of hematopoietic stem cells, featuring abnormal hematopoietic cell development and ineffective hematopoiesis. Animal models are an important scientific research platform that has been widely applied in the research of human diseases, especially tumors. Animal models with MDS can simulate characteristic human genetic variations and tumor phenotypes. They also provide a reliable platform for the exploration of the pathogenesis and diagnostic markers of MDS as well as for a drug efficacy evaluation. This paper reviews the research status of three animal models and a new spontaneous mouse model with MDS.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1699-3055
1699-3055
DOI:10.1007/s12094-022-02931-7