A CONCISE SYNTHESIS OF (-)-CYTOXAZONE

A concise, stereoselective synthesis of ((-)-cytoxazone 1 was described. A key feature is highly diastereoselective reduction of the amino ketone to give the anti-amino alcohol directly, which is 2-oxazolidinone precursor.

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Bibliographic Details
Published inHeterocycles Vol. 75; no. 11; pp. 2817 - 2824
Main Authors Pham, Van-Thoai, Joo, Jae-Eun, Tian, Yong-Shou, Kim, Yong-Hyun, Lee, Kee-Young, Oh, Chang-Young, Jeong, Jin-Hyun, Ham, Won-Hun
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.11.2008
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
D-4-Hydroxyphenylglycine
Cytoxazone
CYTOKINE MODULATOR
SPHINGOSINE
2-Oxazolidinone Derivative
Amino-Alcohol Derivative
Regioselective Intramolecular Cyclization
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Summary:A concise, stereoselective synthesis of ((-)-cytoxazone 1 was described. A key feature is highly diastereoselective reduction of the amino ketone to give the anti-amino alcohol directly, which is 2-oxazolidinone precursor.
ISSN:0385-5414
DOI:10.3987/COM-08-11446