Pharmacological data and technical feasibility of intraperitoneal 5-fluorouracil administration

Via a surgically implanted Tenckhoff catheter, 5-fluorouracil was intraperitoneally administered to patients with malignant disease confined to abdominal space. Treatment was well tolerated without local complications. Peritoneal and plasmatic drug levels were measured, showing that: 1) peritoneal d...

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Bibliographic Details
Published inTumori Vol. 68; no. 5; p. 437
Main Authors Demicheli, R, Jirillo, A, Bonciarelli, G, Bellini, A, Petrosino, L, Bigi, L, Garusi, G F
Format Journal Article
LanguageEnglish
Published United States 31.10.1982
Subjects
Aged
Female
Fluorouracil - administration & dosage
Fluorouracil - adverse effects
Fluorouracil - metabolism
Humans
Injections, Intraperitoneal
Male
Middle Aged
Neoplasms - drug therapy
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Summary:Via a surgically implanted Tenckhoff catheter, 5-fluorouracil was intraperitoneally administered to patients with malignant disease confined to abdominal space. Treatment was well tolerated without local complications. Peritoneal and plasmatic drug levels were measured, showing that: 1) peritoneal drug levels declined as a first order function; 2) plasmatic levels were very close to those reported for continuous i.v. administration, but peritoneal concentrations were much higher (log 1 to 3); 3) concentration x time product had a peritoneum: plasma ratio ranging from 120 to 1350. The hypothesized role of intraperitoneal 5-fluorouracil administration and the questions still to be answered are summarized.
ISSN:0300-8916
DOI:10.1177/030089168206800514