Development of ciprofloxacin-loaded polymeric nanoparticles for drug delivery

• Published in: Polymer bulletin (Berlin, Germany) Vol. 81; no. 7; pp. 6555 - 6569
• Main Authors: Kuşat, Kevser, Akgöl, Sinan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2024; Springer Nature B.V
• Subjects: Addition polymerization; Antibiotics; Antimicrobial agents; Bacterial infections; Bioavailability; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Drug delivery systems; Emulsion polymerization; Histidine; Infrared analysis; Kinetics; Morphology; Nanomaterials; Nanoparticles; Organic Chemistry; Original Paper; Physical Chemistry; Polydispersity; Polyhydroxyethyl methacrylate; Polymer Sciences; Size distribution; Soft and Granular Matter; Surfactants; Zeta potential; Japan; Slow release; Polymeric nanoparticles; Ciprofloxacin; Controlled release
• ISSN: 0170-0839; 1436-2449
• DOI: 10.1007/s00289-023-05021-y

Studies in which polymeric nanoparticles are used in drug delivery have been one of the subjects of interest in recent years. In this study, histidine-containing polymeric nanoparticles [poly(2-hydroxyethyl methacrylate-co-N-methacryloylamido histidine methyl ester)] were synthesized by surfactant free emulsion polymerization method. Ciprofloxacin was loaded onto the HPCNs surface [CIP-HCPNs]. In the characterization of CIP-HCPNs, scanning electron microscopy, Fourier-infrared analysis, surface area calculations and zeta potential analysis were used. FT-IR data of histidine-free polymeric nanoparticles [HFPNs] and HCPNs demonstrated the successful addition of Histidine to polymeric nanoparticles. SEM images showed that CIP-HCPNs had a size of 131.2 nm with a spherical shape. As a result of Zeta potential studies, the polydispersity index (PDI) of CIP-HCPNs was found to be 0.11, indicating that CIP-HCPNs have a narrowly spaced size distribution. CIP release from CIP-HCNPs showed slow-release properties. At pH 7.4, cumulative CIP release from CIP-HCPNs was 96% (283.35 mg/g) within 6 h, with full drug release achieved at 24 h. It was stated that the drug release kinetic data obtained from CIP release experiments fit the Hixson-Crowell model, and in this model, CIP release from CIP-HCPNs occurred as the square root of the time dependent process based on Fickian diffusion. As a result, CIP-HCNPs developed in the current study, it can be said that it is suitable for drug release.