Preliminary observations in cortical excitability changes using transcranial magnetic stimulation (TMS), it’s correlation with diffusion tensor imaging (DTI) in subjects with neuromyelitis optica spectrum disorder (NMOSD)

• Published in: Acta neurologica Belgica Vol. 125; no. 2; pp. 455 - 462
• Main Authors: Shaik, R. S., Ganaraja, V. H., Bhattacharya, A., Kumar, Manoj, Nitish, L. K., Bhat, M., Pal, P. K., Mahadevan, A., Netravathi, M.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2025
• Subjects: Adult; Aquaporin 4 - immunology; Biomedical and Life Sciences; Biomedicine; Cortical Excitability - physiology; Diffusion Tensor Imaging - methods; Evoked Potentials, Motor - physiology; Female; Humans; Male; Medicine/Public Health; Middle Aged; Neurology; Neuromyelitis Optica - diagnostic imaging; Neuromyelitis Optica - physiopathology; Neuroradiology; Neurosciences; Prospective Studies; Transcranial Magnetic Stimulation - methods; Young Adult; Cortical excitability; NMOSD (Neuromyelitis Optica Spectrum Disorder); MOG (myelin oligodendrocyte glycoprotein); TMS (transcranial magnetic stimulation)
• ISSN: 0300-9009; 2240-2993; 2240-2993
• DOI: 10.1007/s13760-025-02718-x

Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing central nervous system disease most commonly associated with aquaporin-4 antibodies (AQP4-Ab) and Myelin oligodendrocyte glycoprotein (MOG) antibodies. These demyelinating disorders influence cortical excitability, which has been studied using advanced imaging techniques and transcranial magnetic stimulation (TMS) in our study. Methods This is a prospective study of 30 subjects. Ten subjects, each of AQP4, MOGAD, and dual seronegative (SN)-NMOSD, were recruited and compared to 30 healthy controls. All the subjects underwent TMS and MRI with diffusion tensor imaging (DTI). Resting motor threshold (RMT), central motor conduction time (CMCT), ipsilateral (ISP) and contralateral silent period (cSP), short interval intracortical inhibition (SICI) and intracortical facilitation (ICF) were the TMS parameters assessed. Fractional anisotropy (FA) and axial diffusivity (AD) were the DTI parameters studied. DTI findings were correlated with the TMS parameters. Results The study cohort had a male-to-female ratio of (M: F) = 13:17. RMT was highest in the AQP4-Ab subgroup (40.2 ± 11.9%) compared to SN NMOSD (36.2 ± 4.6%) and MOGAD (34.5 ± 6.7%). CMCT was maximum prolonged in subjects with MOGAD (9.6 ± 1.9 msec). The cSP was reduced in MOGAD (79.9 ± 36.3msec). SICI was lowest in the AQP4-Ab subgroup (1.27 ± 1.12) and was preserved in the MOGAD subgroup (0.88 ± 0.55). The DTI data demonstrated statistically significant, reduced FA and AD in AQP4-Ab and SN NMOSD subjects. Conclusion This is the first study that looked at the cortical excitability changes in the three subgroups of NMOSD. It has been observed that AQP4 NMOSD and SN NMOSD had a severe form of demyelinating disease compared to MOGAD.