Rewiring of metabolic pathways in yeasts for sustainable production of biofuels

• Published in: Bioresource technology Vol. 372; p. 128668
• Main Authors: Maurya, Rupesh, Gohil, Nisarg, Nixon, Snovia, Kumar, Nilesh, Noronha, Santosh B., Dhali, Debarun, Trabelsi, Heykel, Alzahrani, Khalid J., Reshamwala, Shamlan M.S., Awasthi, Mukesh Kumar, Ramakrishna, Suresh, Singh, Vijai
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2023
• Subjects: Biofuels; Fatty acids; Metabolic Engineering; Metabolic Networks and Pathways; Microbial cell factories; Saccharomyces cerevisiae - metabolism; Terpenes - metabolism; Yeast; Metabolic engineering; Yeast; Biofuels; Microbial cell factories; Fatty acids
• ISSN: 0960-8524; 1873-2976
• DOI: 10.1016/j.biortech.2023.128668

[Display omitted] •Recent advances in biofuel production using engineered yeasts cells•Engineering approaches used for enhanced biofuels production in yeast cell factories•Strategies for production of advanced biofuels using engineered yeasts•Non-conventional yeasts as cell factories for biofuel production The ever-increasing global energy demand has led world towards negative repercussions such as depletion of fossil fuels, pollution, global warming and climate change. Designing microbial cell factories for the sustainable production of biofuels is therefore an active area of research. Different yeast cells have been successfully engineered using synthetic biology and metabolic engineering approaches for the production of various biofuels. In the present article, recent advancements in genetic engineering strategies for production of bioalcohols, isoprenoid-based biofuels and biodiesels in different yeast chassis designs are reviewed, along with challenges that must be overcome for efficient and high titre production of biofuels.