Electrochemiluminescent detection of doping drugs in sports using metal-organic frameworks (MOFs)

• Published in: International journal of electrochemical science Vol. 19; no. 5; p. 100552
• Main Authors: Bin Xie, Zhang, Fuye
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.05.2024
• Subjects: Anti-doping; Detection; Electrochemiluminescence; Metal-organic frameworks; Porosity; Anti-doping; Electrochemiluminescence; Porosity; Detection; Metal-organic frameworks
• ISSN: 1452-3981; 1452-3981
• DOI: 10.1016/j.ijoes.2024.100552

This review examines recent progress and prospects in applying metal-organic frameworks (MOFs) to enhance electrochemiluminescence (ECL) for anti-doping analysis. The unique properties of MOFs make them excellent materials to boost ECL sensing performance. Their ultrahigh porosity facilitates immobilization of ECL reagents at high loadings without self-quenching. Rigid yet porous architectures provide biocompatible microenvironments to stabilize reactive intermediates. Large surface areas enable target capture and preconcentration even from complex biosamples. Several studies demonstrate sensitive ECL detection of prohibited performance enhancing substances down to very low concentrations using MOF-coupled platforms. However, issues remain regarding physiological interactions, synthesis optimization, and device integration for field applications. But initial successes highlight the advantages of synergistically merging advanced optical porous nanomaterials with electrochemical emissive readout. This could provide next-generation assay capabilities to combat evolving doping threats and reliably identify illicit performance enhancing agents across a wide range of sports. Overall, the creative combination of metal-organic frameworks with electrochemiluminescence sensing holds exciting potential for anti-doping efforts.