Factors associated with early-onset intracranial aneurysms in patients with autosomal dominant polycystic kidney disease
Background Recently, the importance of attribute-based medicine has been emphasized. The effects of early-onset intracranial aneurysms on patients can be significant and long-lasting. Herein, we compared the factors associated with intracranial aneurysms in patients with autosomal dominant polycysti...
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Published in | Journal of nephrology Vol. 37; no. 4; pp. 983 - 992 |
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Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Cham
Springer International Publishing
01.05.2024
|
Subjects | |
Online Access | Get full text |
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Summary: | Background
Recently, the importance of attribute-based medicine has been emphasized. The effects of early-onset intracranial aneurysms on patients can be significant and long-lasting. Herein, we compared the factors associated with intracranial aneurysms in patients with autosomal dominant polycystic kidney disease (ADPKD) according to age categories (≥ 50 years, < 50 years).
Methods
We included 519 ADPKD patients, with a median age of 44 years, estimated glomerular filtration rate of 54.5 mL/min/1.73 m
2
, and total follow-up duration of 3104 patient-years. Logistic regression analyses were performed to determine factors associated with intracranial aneurysms.
Results
Regarding the presence of intracranial aneurysm, significant interactions were identified between the age category (age ≥ 50 years), female sex (
P
= 0.0027 for the interaction) and hypertension (
P
= 0.0074 for the interaction). Female sex and hypertension were associated with intracranial aneurysm risk factors only in patients aged ≥ 50 years. The presence of intracranial aneurysm was significantly associated with chronic kidney disease (CKD) stages 4–5 (odds ratio [OR] = 3.87,
P
= 0.0007) and family history of intracranial aneurysm or subarachnoid hemorrhage (OR = 2.30,
P
= 0.0217) in patients aged < 50 years. For patients aged ≥ 50 years, in addition to the abovementioned factors [OR = 2.38,
P
= 0.0355 for CKD stages 4–5; OR = 3.49,
P
= 0.0094 for family history of intracranial aneurysm or subarachnoid hemorrhage], female sex (OR = 4.51,
P
= 0.0005), and hypertension (OR = 5.89,
P
= 0.0012) were also associated with intracranial aneurysm.
Conclusion
Kidney dysfunction and family history of intracranial aneurysm or subarachnoid hemorrhage are risk factors for early-onset intracranial aneurysm. Patients aged < 50 years with a family history of intracranial aneurysm or subarachnoid hemorrhage or with CKD stages 4–5 may be at an increased risk of early-onset intracranial aneurysm.
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1724-6059 1724-6059 |
DOI: | 10.1007/s40620-023-01866-8 |