Phospholipid bilayers in model membranes and drug delivery systems: from physics to pharmacy

Abstract Lipids spontaneously aggregate in an aqueous environment forming supramolecular structures of various architectures known as liquid crystalline mesophases. Their thermodynamic properties determined by dual polar/apolar nature coupled with the possibility to modulate the structural parameter...

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Published inEUROPEAN PHARMACEUTICAL JOURNAL Vol. 68; no. 1; pp. 66 - 71
Main Author Uhríková, D.
Format Journal Article
LanguageEnglish
Published Warsaw De Gruyter Poland 01.01.2021
Sciendo
Subjects
Antimicrobial agents
antimicrobial peptides
Drug delivery systems
lipid bilayer
lipoplexes
non-lamellar phases
pulmonary surfactant
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Summary:Abstract Lipids spontaneously aggregate in an aqueous environment forming supramolecular structures of various architectures known as liquid crystalline mesophases. Their thermodynamic properties determined by dual polar/apolar nature coupled with the possibility to modulate the structural parameters, phase geometry and stability are challenging for applications in drug delivery systems. We review a few examples of functionality of lipid bilayers.
ISSN:2453-6725
2453-6725
DOI:10.2478/afpuc-2021-0008