Plant‐Derived Chinese Herbal Hydrogel Microneedle Patches for Wound Healing

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 20; no. 45; pp. e2404850 - n/a
• Main Authors: Luan, Qichen, Qiao, Ruochen, Wu, Xiangyi, Shan, Jingyang, Song, Chuanhui, Zhao, Xiaozhi, Zhao, Yuanjin
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 28.07.2024
• Subjects: Aloe; aloes; Antiinfectives and antibacterials; berberine; Chinese medicine; Drug delivery systems; Harnesses; hydrogel; Hydrogels; microneedles; Needles; patches; Traditional Chinese medicine; Wound healing; microneedles; wound healing; aloes; hydrogel; patches; berberine
• ISSN: 1613-6810; 1613-6829; 1613-6829
• DOI: 10.1002/smll.202404850

Several natural Chinese herbal medicines have demonstrated considerable potential in facilitating wound healing, while the primary concern remains centered around optimizing formulation and structure to maximize their efficacy. To address this, a natural microneedles drug delivery system is proposed that harnesses gelatinized starch and key Chinese herbal ingredients—aloe vera and berberine. After gelatinized and aged in a well‐designed mold, the starch‐based microneedles are fabricated with suitable mechanical strength to load components. The resulting Chinese herbal hydrogel microneedles, enriched with integrated berberine and aloe, exhibit antibacterial, anti‐inflammatory, and fibroblast growth‐promoting properties, thereby facilitating wound healing in the whole process. In vivo experimental results underscore the notable achievements of the microneedles in early‐stage antibacterial effects and subsequent tissue reconstruction, contributing significantly to the overall wound healing process. These results emphasize the advantageous combination of traditional Chinese medicine with microneedles, presenting a novel strategy for wound repair and opening new avenues for the application of traditional Chinese medicine. A natural microneedles drug delivery system (BBRMN) is prepared with aloe and water chestnut starch, and berberine is used as the loading drug. BBRMN is prepared by micromachining the hydrogel with a mold. After being applied to the infected wound, the BBRMN could inhibit bacterial and inflammatory cytokine production in infected wounds, promoting wound healing.