IsoDGR-Tagged Albumin: A New αvβ3 Selective Carrier for Nanodrug Delivery to Tumors

A new cyclic peptide containing the isoDGR motif that, after coupling to albumin, selectively binds αvβ3, an integrin overexpressed in the tumor vasculature. IsoDGR‐tagged albumin binds tumor vessels and can be exploited as a carrier for the preparation of tumor vasculature‐selective nanomedicines,...

Full description

Saved in:
Bibliographic Details
Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 9; no. 5; pp. 673 - 678
Main Authors Curnis, Flavio, Sacchi, Angelina, Longhi, Renato, Colombo, Barbara, Gasparri, Anna, Corti, Angelo
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 11.03.2013
WILEY‐VCH Verlag
Subjects
cyclic peptides
drug delivery
Gold - chemistry
gold nanoparticles
human serum albumin
Humans
Integrin alphaVbeta3 - administration & dosage
Integrin alphaVbeta3 - chemistry
Metal Nanoparticles - chemistry
Neoplasms - metabolism
Tumor Necrosis Factor-alpha - chemistry
tumor necrosis factors
Online AccessGet full text

Cover

More Information
Summary:A new cyclic peptide containing the isoDGR motif that, after coupling to albumin, selectively binds αvβ3, an integrin overexpressed in the tumor vasculature. IsoDGR‐tagged albumin binds tumor vessels and can be exploited as a carrier for the preparation of tumor vasculature‐selective nanomedicines, such as gold nanoparticles (Au) carrying tumor necrosis factor α (TNF), a potent vascular damaging agent.
Bibliography:ArticleID:SMLL201202310
istex:62486A2EE091B9671039F2A1BB9AFC667D02FFEB
ark:/67375/WNG-PQ4HKS6P-D
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201202310