Recent Advances in the Synthesis of Diarylheptanoids

In the quest for synthesizing biologically important natural products, medicinal chemists embark on an endless journey. This review focuses on the reports published towards the syntheses of diarylheptanoids, classifying them into linear, tetrahydropyran, diarylether, and biphenyl categories. The syn...

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Published inChemistry, an Asian journal Vol. 19; no. 15; pp. e202400380 - n/a
Main Authors Sudarshan, Kasireddy, Yarlagadda, Suresh, Sengupta, Sagnik
Format Journal Article
LanguageEnglish
Published Germany 01.08.2024
Subjects
Biological Products - chemical synthesis
Biological Products - chemistry
Centrolobine
Curcumin
Diarylheptanoids
Diarylheptanoids - chemical synthesis
Diarylheptanoids - chemistry
Macrocyclization
Molecular Structure
Olefin metathesis
Curcumin
Olefin metathesis
Diarylheptanoids
Macrocyclization
Centrolobine
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Summary:In the quest for synthesizing biologically important natural products, medicinal chemists embark on an endless journey. This review focuses on the reports published towards the syntheses of diarylheptanoids, classifying them into linear, tetrahydropyran, diarylether, and biphenyl categories. The synthesis methods for each class from 2013 to 2023 are discussed, providing a comprehensive overview of the advancements in the field. Representative natural product examples are highlighted for each category. The review emphasizes the importance of diarylheptanoids in the realms of chemistry and medicine, showcasing their potential as valuable compounds for medicinal and synthetic chemists. A review covering the total syntheses of biologically significant class of diarylheptanoids during the period 2013–2023. This review covers 35 natural diarylheptanoids across linear, tetrahydropyran, diarylether and biphenyl diarylheptanoids.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202400380