Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer’s disease using 11C-Pittsburgh Compound-B

• Published in: Annals of nuclear medicine Vol. 37; no. 7; pp. 410 - 418
• Main Authors: Tada, Tomohiro, Hara, Kazuhiro, Fujita, Naotoshi, Ito, Yoshinori, Yamaguchi, Hiroshi, Ohdake, Reiko, Kawabata, Kazuya, Ogura, Aya, Kato, Toshiyasu, Yokoi, Takamasa, Masuda, Michihito, Abe, Shinji, Miyao, Shinichi, Naganawa, Shinji, Katsuno, Masahisa, Watanabe, Hirohisa, Sobue, Gen, Kato, Katsuhiko
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 2023; Springer Nature B.V
• Subjects: Alzheimer's disease; Amyloid; Cerebellum; Cognitive ability; Corpus callosum; Cortex; Emission analysis; Image processing; Imaging; Magnetic resonance imaging; Medical imaging; Medicine; Medicine & Public Health; Neurodegenerative diseases; Neuroimaging; Nuclear Medicine; Original; Original Article; Pons; Positron emission; Positron emission tomography; Quantitative analysis; Radiology; Three dimensional analysis; Tomography; C-Pittsburgh Compound-B; Brain; Alzheimer’s disease; Standardised uptake value ratio; Positron emission tomography imaging
• ISSN: 0914-7187; 1864-6433
• DOI: 10.1007/s12149-023-01843-y

Objectives Standardised uptake value ratio (SUVR) is usually obtained by dividing the SUV of the region of interest (ROI) by that of the cerebellar cortex. Cerebellar cortex is not a valid reference in cases where amyloid β deposition or lesions are present. Only few studies have evaluated the use of other regions as references. We compared the validity of the pons and corpus callosum as reference regions for the quantitative evaluation of brain positron emission tomography (PET) using 11 C-PiB compared to the cerebellar cortex. Methods We retrospectively evaluated data from 86 subjects with or without Alzheimer’s disease (AD). All subjects underwent magnetic resonance imaging, PET imaging, and cognitive function testing. For the quantitative analysis, three-dimensional ROIs were automatically placed, and SUV and SUVR were obtained. We compared these values between AD and healthy control (HC) groups. Results SUVR data obtained using the pons and corpus callosum as reference regions strongly correlated with that using the cerebellar cortex. The sensitivity and specificity were high when either the pons or corpus callosum was used as the reference region. However, the SUV values of the corpus callosum were different between AD and HC (p < 0.01). Conclusions Our data suggest that the pons and corpus callosum might be valid reference regions.