Association of CTLA4 Gene Polymorphisms with Rheumatoid Arthritis Susceptibility

• Published in: Genetic testing and molecular biomarkers Vol. 29; no. 6; p. 166
• Main Authors: Albahar, Abdullah, Torktaz, Ibrahim, Houshmand, Massoud
• Format: Journal Article
• Language: English
• Published: United States 01.06.2025
• Subjects: Adult; Aged; Arthritis, Rheumatoid - genetics; Case-Control Studies; CTLA-4 Antigen - genetics; CTLA-4 Antigen - metabolism; Female; Gene Frequency - genetics; Genetic Markers - genetics; Genetic Predisposition to Disease - genetics; Genotype; Haplotypes - genetics; Humans; Iran; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; Iran; CTLA4; immunity; single nucleotide polymorphism; rheumatoid arthritis; rheumatoid factor
• ISSN: 1945-0257
• DOI: 10.1089/gtmb.2025.0086

Rheumatoid arthritis (RA) is a chronic inflammatory disease, presenting with joint inflammation and its progressive destruction, affecting a range of about 0.24-1% of the population in different parts of the world. It is one of the major disabling conditions among middle-aged and older women. In this study, the association between five single nucleotide polymorphisms (SNPs) of the CTLA4 gene and RA was investigated. The study group included 200 patients with RA and 184 healthy individuals from the Iranian population as a control group. Results: After PCR and genotyping, 4 of the 5 SNPs studied showed a significant association with RA. Also, an association between specific haplotypes with RA was determined. Based on the results, it can be said that some SNPs of the CTLA4 gene may serve as genetic markers for predicting RA susceptibility or progression and using personalized treatment, lead to improved outcomes among patients with RA.