Serum cholecystokinin concentrations in dogs with naturally acquired pituitary-dependent hyperadrenocorticism

• Published in: American journal of veterinary research Vol. 77; no. 10; p. 1101
• Main Authors: Noh, Sungjun, Kim, Hye-Sun, Chang, Jinhwa, Kang, Ji-Houn, Chang, Dongwoo, Yang, Mhan-Pyo
• Format: Journal Article
• Language: English
• Published: United States 01.10.2016
• Subjects: Adrenocortical Hyperfunction - blood; Adrenocortical Hyperfunction - veterinary; Animals; Case-Control Studies; Cholecystokinin - blood; Cholesterol - blood; Dihydrotestosterone - analogs & derivatives; Dihydrotestosterone - therapeutic use; Dog Diseases - blood; Dog Diseases - diagnostic imaging; Dog Diseases - drug therapy; Dogs; Enzyme Inhibitors - therapeutic use; Female; Gallbladder Diseases - blood; Gallbladder Diseases - veterinary; Hydrocortisone - blood; Male
• ISSN: 1943-5681
• DOI: 10.2460/ajvr.77.10.1101

OBJECTIVE To determine serum cholecystokinin (CCK) concentrations in dogs with pituitary-dependent hyperadrenocorticism (PDH) and to evaluate associations among CCK concentration, PDH, and gallbladder mucocele (GBM). ANIMALS 14 client-owned dogs with PDH and 14 healthy dogs. PROCEDURES Dogs were separated into 4 groups: healthy dogs without gallbladder sludge (group A; n = 7), healthy dogs with gallbladder sludge (group B; 7), dogs with PDH and gallbladder sludge (group C; 8), and dogs with PDH and GBM (group D; 6). Serum CCK concentrations were then measured before and 1, 2, and 4 hours after consumption of a high-fat meal. Concentrations in dogs with PDH were also measured before and after trilostane treatment. Results were compared among groups and assessment points. RESULTS Preprandial serum CCK concentrations in group C were significantly lower than those in groups A, B, and D, but no significant differences in postprandial CCK concentrations were identified among the groups 1, 2, or 4 hours after the meal. With respect to trilostane treatment of dogs with PDH, no significant differences were identified between pre- and post-trilostane serum CCK concentrations in group C or D. Median CCK concentration after trilostane treatment was higher in group D than in group C, but this difference was not significant. CONCLUSIONS AND CLINICAL RELEVANCE The outcomes in this study did not support the hypothesis that a low circulating CCK concentration affects the development of GBM in dogs with PDH.