Flexible non-invasive sensor for neurotransmitter monitoring inspired by AgBiS2/PEDOT:PSS

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Vol. 476; p. 146591
• Main Authors: Mishra, Vijayalaxmi, Krishnapandi, Alagumalai, Arumugam, Bharathi, Kim, Seong-Cheol
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.11.2023
• Subjects: AgBiS2/PEDOT:PSS; Human fluids; Non-invasive dopamine sensor; Ultrasonic approach; Ultrasonic approach; Human fluids; AgBiS2/PEDOT:PSS; Non-invasive dopamine sensor
• ISSN: 1385-8947; 1873-3212
• DOI: 10.1016/j.cej.2023.146591

AgBiS2-reinforced conducting polymer PEDOT:PSS-modified glassy carbon electrode is employed for monitoring dopamine in human fluids. [Display omitted] •Ultrasonically developed AgBiS2/PEDOT:PSS/GCE sensor used for neurotransmitter detection.•Sensor exhibited a lower impedance (28 Ω) compared to other modified electrodes.•Showed impressive results, lower LOD (0.0026 µM), good linear range (0.0875–937.5 µL), and good sensitivity (1.4872 µA µM−1 cm−2).•It revealed good specificity in the presence of uric acid, ascorbic acid, and glucose. The neurotransmitter dopamine plays an essential role in determining human psychological behavior, and its abnormality can lead to severe psychological diseases. Therefore, rapid assessment and initial diagnosis are crucial. In this study, a AgBiS2/PEDOT:PSS in the composite material contributes to its improved performance as an electrochemical sensor. The developed AgBiS2/PEDOT:PSS/GCE electrode exhibited a lower impedance (28 Ω) compared to other modified electrodes. It demonstrated a low limit of detection (0.0026 µM), high sensitivity (1.4872 µA µM−1 cm−2), a wide linear range (0.0875–937.5 µM) and good reproducibility and repeatability. Furthermore, the sensor showed exceptional selectivity even in the presence of potential interfering substances such as glucose, ascorbic acid, and uric acid. Satisfactory recovery results were obtained for the detection of dopamine in human fluids, including blood, urine, and saliva.