Is there a lesser hyperparathyroidism in diabetic patients with chronic renal failure?

• Published in: Nephrology, dialysis, transplantation Vol. 13; no. 90003; pp. 9 - 11
• Main Authors: MARTINEZ, I, SARACHO, R, MOINA, I, MONTENEGRO, J, LLACH, F
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.01.1998
• Subjects: Adult; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood Glucose - analysis; Diabetic Nephropathies - blood; Emergency and intensive care: renal failure. Dialysis management; Female; Humans; Hypoparathyroidism - etiology; Intensive care medicine; Kidney Failure, Chronic - blood; Magnesium - blood; Male; Medical sciences; Middle Aged; Parathyroid Hormone - blood; Endocrinopathy; Kidney disease; Human; Urinary system disease; Diabetes mellitus; Epidemiology; Peritoneal dialysis; Incidence; Extrarenal dialysis; Chronic; Treatment; Parathyroid diseases; Renal failure; Complication; Biological effect; Hyperparathyroidism
• ISSN: 0931-0509; 1460-2385; 1460-2385
• DOI: 10.1093/ndt/13.suppl_3.9

Diabetic patients on dialysis have lower levels of parathyroid hormone (PTH); however, there is no data regarding PTH levels with different degrees of chronic renal failure (CRF). We compared 58 diabetic patients with different degrees of CRF with 268 non-diabetic patients with CRF (serum creatinine >1.2 mg/dl). In both groups, we investigated the main biochemical parameters together with plasma calcium, phosphorus, magnesium, PTH and calcitriol. Diabetic patients showed lower levels of PTH than non-diabetics (P=0.003). The differences were observed in patients with creatinine clearance <70ml/min. We also observed differences in phosphorus, magnesium and tubular resorption of phosphate. In the group of diabetic patients, serum glucose correlated inversely with PTH. Our study suggests that poor control of diabetes (hyperglycaemia) may play a role in the pathogenesis of the hypoparathyroidism observed in patients with diabetes and CRF.