Evaluation of carbon-11 labelled phenylglycine and phenylalanine for pancreas scintigraphy

Carbon-11 (t1/2 equals 20.4 min, beta-+) labelled DL-alpha-phenylalanine and DL-alpha-phenylglycine were administered intravenously to rats and the distribution of the radioactive amino acids over pancreas, liver, spleen, kidneys and blood was measured after several time intervals. From these result...

Full description

Saved in:
Bibliographic Details
Published inNuclear-Medizin Vol. 14; no. 1; p. 60
Main Authors Vaalburg, W, Beerling-van der Molen, H D, Woldring, M G
Format Journal Article
LanguageEnglish
Published Germany 01.01.1975
Subjects
Animals
Carbon Radioisotopes
Evaluation Studies as Topic
Fluorine
Glycine - metabolism
Injections, Intravenous
Isotope Labeling - methods
Kidney - metabolism
Liver - metabolism
Male
Pancreas - metabolism
Pancreatic Diseases - diagnosis
Phenylacetates
Phenylalanine - metabolism
Radioisotopes
Radionuclide Imaging
Rats
Selenium
Spleen - metabolism
Online AccessGet more information

Cover

More Information
Summary:Carbon-11 (t1/2 equals 20.4 min, beta-+) labelled DL-alpha-phenylalanine and DL-alpha-phenylglycine were administered intravenously to rats and the distribution of the radioactive amino acids over pancreas, liver, spleen, kidneys and blood was measured after several time intervals. From these results the ratios of the concentration in pancreas and liver were calculated and compared with the corresponding ratios from the literature for some 18-F-labelled aromatic amino acids and L-selenomethionine-75-Se. On the basis of this study it appears that DL-alpha-phenylglycine-1-11-C, in spite of a small percentage of the administered dose reaching the pancreas, and DL-alpha-phenylalanine-1-11-C are better suited to pancreas scintigraphy than L-selenomethionine-75-Se.
DOI:10.1055/s-0038-1624886