Cost Savings and Efficacy in Management of Paracetamol Poisoning in a 23-hours Emergency Department Observation Unit: A Comparison to Inpatient Care

• Published in: Curēus (Palo Alto, CA) Vol. 11; no. 12; p. e6294
• Main Authors: Kuan, Kelvin K, Lim, Hoon Chin, Goh, Geraldine, Arciaga, Gabriel S, Goh, Pak Liang, Mong, Rupeng, Chow, Wai Leng, Tan, Hock Heng
• Format: Journal Article
• Language: English
• Published: United States Cureus Inc 05.12.2019; Cureus
• Subjects: Analgesics; Cost control; Emergency Medicine; Epidemiology/Public Health; Financial analysis; Generalized linear models; Hospitals; Internal Medicine; Patients; Performance evaluation; Poisoning; United States > US; Singapore; acetaminophen; n-acetylcysteine; poisoning; hepatotoxicity; length of stay; observation ward; paracetamol; cost-savings
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.6294

Introduction Emergency department observation units (EDOU) have been shown to be effective in decreasing hospitalization rates and length of stay (LOS) for various conditions. However, cost savings and efficacy in the management of poisoning in EDOU have not been widely studied. The objective of our study is to compare the costs and effectiveness of managing paracetamol poisoned patients in the EDOU with those treated in the inpatient wards. Methods We conducted a historical controlled observational study comparing paracetamol-poisoned patients (who received at least 21 hours of IV N-acetylcysteine [NAC]) admitted to the EDOU during 2013-2014 with similar patients admitted to inpatient ward during 2011, 2013-2014.  Results We found 136 patients admitted to the inpatient ward and 95 to our EDOU due to paracetamol poisoning but only 78 and 39 patients respectively fulfilled the inclusion criteria. Between the EDOU and inpatient ward groups, we found similar demographics, poisoning presentation, treatment, and adverse event profiles. There were no fatalities and only two patients (one from each group) developed hepatotoxicity. The "medical" length of stay was 31.9 hours shorter in the EDOU group compared to the inpatient ward group (23.3 versus 55.2 hours). EDOU patients have statistically significant savings (comparing bill size) of S$784 per patient. Conclusions Admission to the EDOU resulted in significant cost savings and 58% decreased LOS when compared to inpatient wards. The EDOU is a cost-effective and safe alternative for the management of selected paracetamol poisonings requiring NAC. Further studies would be needed to verify these results.